Sjögren syndrome: advances in the pathogenesis from animal models

doi:10.1016/j.jaut.2009.09.009

Review

. 2009 Nov-Dec;33(3-4):190-6.

doi: 10.1016/j.jaut.2009.09.009. Epub 2009 Oct 2.

Sjögren syndrome: advances in the pathogenesis from animal models

J A Chiorini¹, D Cihakova, C E Ouellette, P Caturegli

Affiliations

Affiliation

¹ Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA.

PMID: 19800762
PMCID: PMC3439154
DOI: 10.1016/j.jaut.2009.09.009

Review

Sjögren syndrome: advances in the pathogenesis from animal models

J A Chiorini et al. J Autoimmun. 2009 Nov-Dec.

. 2009 Nov-Dec;33(3-4):190-6.

doi: 10.1016/j.jaut.2009.09.009. Epub 2009 Oct 2.

Authors

J A Chiorini¹, D Cihakova, C E Ouellette, P Caturegli

Affiliation

¹ Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA.

PMID: 19800762
PMCID: PMC3439154
DOI: 10.1016/j.jaut.2009.09.009

Abstract

Sjögren syndrome is an autoimmune disease characterized by hyposecretion of the lacrimal and salivary glands, resulting in dryness of the eyes and mouth. Individuals may experience primary Sjögren syndrome or a secondary form accompanying another rheumatic autoimmune disease, such as rheumatoid arthritis or systemic lupus erythematosus. The pathogenic mechanisms of Sjögren syndrome remain largely unknown, in part a consequence of the heterogeneity of the disease. Animal models have shed light on the connections between specific pathways and symptoms, but an ideal system is wanting. Improved disease models will enable a better understanding of Sjögren syndrome, including how immune tolerance is lost and potential therapeutic interventions. Most importantly, an optimal model will enable detection of disease biomarkers, since injury to the salivary glands may precede lymphocytic infiltration. This review aims to characterize available mice models of Sjögren syndrome, including advantages and disadvantages, from the researcher's perspective.

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References

1. Fox RI. Sjogren’s syndrome. Lancet. 2005;366:321–331. - PubMed
1. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis. 2002;61:554–558. - PMC - PubMed
1. Morbini P, Manzo A, Caporali R, Epis O, Villa C, Tinelli C, et al. Multilevel examination of minor salivary gland biopsy for Sjogren’s syndrome significantly improves diagnostic performance of AECG classification criteria. Arthritis Res Ther. 2005;7:R343–R348. - PMC - PubMed
1. Galvez J, Saiz E, Lopez P, Pina MF, Carrillo A, Nieto A, et al. Diagnostic evaluation and classification criteria in Sjogren’s Syndrome. Jt Bone Spine. 2009;76:44–49. - PubMed
1. Venables PJ. Sjogren’s syndrome. Best Pract Res Clin Rheumatol. 2004;18:313–329. - PubMed

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[1] Fox RI. Sjogren’s syndrome. Lancet. 2005;366:321–331. - PubMed

[2] Fox RI. Sjogren’s syndrome. Lancet. 2005;366:321–331. - PubMed

[3] Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis. 2002;61:554–558. - PMC - PubMed

[4] Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis. 2002;61:554–558. - PMC - PubMed

[5] Morbini P, Manzo A, Caporali R, Epis O, Villa C, Tinelli C, et al. Multilevel examination of minor salivary gland biopsy for Sjogren’s syndrome significantly improves diagnostic performance of AECG classification criteria. Arthritis Res Ther. 2005;7:R343–R348. - PMC - PubMed

[6] Morbini P, Manzo A, Caporali R, Epis O, Villa C, Tinelli C, et al. Multilevel examination of minor salivary gland biopsy for Sjogren’s syndrome significantly improves diagnostic performance of AECG classification criteria. Arthritis Res Ther. 2005;7:R343–R348. - PMC - PubMed

[7] Galvez J, Saiz E, Lopez P, Pina MF, Carrillo A, Nieto A, et al. Diagnostic evaluation and classification criteria in Sjogren’s Syndrome. Jt Bone Spine. 2009;76:44–49. - PubMed

[8] Galvez J, Saiz E, Lopez P, Pina MF, Carrillo A, Nieto A, et al. Diagnostic evaluation and classification criteria in Sjogren’s Syndrome. Jt Bone Spine. 2009;76:44–49. - PubMed

[9] Venables PJ. Sjogren’s syndrome. Best Pract Res Clin Rheumatol. 2004;18:313–329. - PubMed

[10] Venables PJ. Sjogren’s syndrome. Best Pract Res Clin Rheumatol. 2004;18:313–329. - PubMed

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Sjögren syndrome: advances in the pathogenesis from animal models

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Sjögren syndrome: advances in the pathogenesis from animal models

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