Role of autophagy in the control of cell death and inflammation

doi:10.4110/in.2009.9.1.8

. 2009 Feb;9(1):8-11.

doi: 10.4110/in.2009.9.1.8. Epub 2009 Feb 28.

Role of autophagy in the control of cell death and inflammation

Myung-Shik Lee¹

Affiliations

PMID: 20107532
PMCID: PMC2803293
DOI: 10.4110/in.2009.9.1.8

Role of autophagy in the control of cell death and inflammation

Myung-Shik Lee. Immune Netw. 2009 Feb.

. 2009 Feb;9(1):8-11.

doi: 10.4110/in.2009.9.1.8. Epub 2009 Feb 28.

Author

Myung-Shik Lee¹

Affiliation

¹ Department of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 135-710, Korea.

PMID: 20107532
PMCID: PMC2803293
DOI: 10.4110/in.2009.9.1.8

Abstract

There is mounting evidence that autophagy is involved in diverse physiological and pathological processes that have immense relevance in human development, diseases and aging. Immunity and inflammation are not exceptions. Here, the role of autophagy in the control of immune processes particularly that related to cell death and inflammation is discussed.

Keywords: apoptosis; autophagy; immunity; inflammation; necrosis.

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Conflict of interest statement

Disclosures: The authors have no financial conflict of interest.

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[1] Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27–42. - PMC - PubMed

[2] Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27–42. - PMC - PubMed

[3] Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007;128:931–946. - PubMed

[4] Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007;128:931–946. - PubMed

[5] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425–434. - PMC - PubMed

[6] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425–434. - PMC - PubMed

[7] Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441:885–889. - PubMed

[8] Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441:885–889. - PubMed

[9] Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441:880–884. - PubMed

[10] Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441:880–884. - PubMed

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Role of autophagy in the control of cell death and inflammation

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Role of autophagy in the control of cell death and inflammation

Author

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Abstract

Conflict of interest statement

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