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. 2010 Jun 5;153B(4):973-9.
doi: 10.1002/ajmg.b.31061.

SNPs in CAST are associated with Parkinson disease: a confirmation study

Andrew S Allen  1 , Glen A Satten
Affiliations

SNPs in CAST are associated with Parkinson disease: a confirmation study

Andrew S Allen et al. Am J Med Genet B Neuropsychiatr Genet. .

Abstract

Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

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Figures

Figure 1
Figure 1
Analysis results from NINDS data reported in Allen and Satten (2009) highlighting follow-up region. Solid red vertical lines denote region comprised of 50 SNPs in the CIDR PD data. Dotted red vertical lines denote extent of SNPs used in haplotype sharing tests.
See this image and copyright information in PMC

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