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. 2011 Feb;25(6):595-617.
doi: 10.1177/0885328209356603. Epub 2010 Mar 5.

Biocompatibility and antibacterial effect of silver doped 3D-glass-ceramic scaffolds for bone grafting

Cristina Balagna  1 , Chiara Vitale-Brovarone, Marta Miola, Enrica Verné, Rosa Angela Canuto, Silvia Saracino, Giuliana Muzio, Giacomo Fucale, Giovanni Maina
Affiliations

Biocompatibility and antibacterial effect of silver doped 3D-glass-ceramic scaffolds for bone grafting

Cristina Balagna et al. J Biomater Appl. 2011 Feb.

Abstract

A 3D-glass-ceramic scaffold for bone tissue engineering with an interconnected macroporous network of pores was doped with silver ions in order to confer antibacterial properties. For this purpose, silver ions were selectively added to the scaffold surfaces through ion-exchange using an aqueous silver nitrate solution. The silver-doped scaffolds were characterized by means of leaching, in vitro antibacterial, and citotoxicity tests. In particular, the silver effect was examined through a broth dilution test in order to evaluate the proliferation of bacteria by counting the colonies forming units. Moreover, cytotoxicity tests were carried out to understand the effect of silver-containing scaffolds on cell adhesion, proliferation, and vitality. For all tests a comparison between silver-doped scaffold and silver-doped scaffold dry sterilized was performed.

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