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. 2010 May;15(5):453-62.
doi: 10.1038/mp.2009.93.

SZGR: a comprehensive schizophrenia gene resource

P Jia  1 , J Sun, A Y Guo, Z Zhao
Affiliations

SZGR: a comprehensive schizophrenia gene resource

P Jia et al. Mol Psychiatry. 2010 May.

Abstract

Schizophrenia is a major debilitating psychiatric disorder affecting approximately 1% of the population worldwide. A tremendous amount of effort has been expended in the last two decades to identify genes influencing susceptibility to this disorder. Although there is a strong trend toward integrating data obtained from various genetic studies and their related biological information into a comprehensive resource for many complex diseases, we were unable to find such an effort for schizophrenia or for any other psychiatric disorder yet. In this study, we present Schizophrenia gene resource (SZGR), a comprehensive database with user-friendly web interface. SZGR deposits genetic data from all available sources, including those from association studies, linkage scans, gene expression, literature, gene ontology (GO) annotations, gene networks, cellular and regulatory pathways, as well as microRNAs and their _target sites. Moreover, SZGR provides online tools for data browse and search, data integration, custom gene ranking and graphical presentation. This system can be easily applied to other complex diseases, especially to other psychiatric disorders. The SZGR database is available at http://bioinfo.mc.vanderbilt.edu/SZGR/.

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Figures

Figure 1
Figure 1
Flowchart of SZGR. It includes data collection, annotations, data integration, gene ranking and database development. GO: Gene Ontology. PPI: Protein-protein interaction. OR: odds ratio.
Figure 2
Figure 2
SZGR web interface. (A) Home page. (B) Search page. (C) Data integration page.
Figure 3
Figure 3
An example gene page in SZGR. (A) Summary of the gene. (B) Data sources. (C) Gene expression profile. (D) Gene Ontology (GO) annotations. (E) KEGG pathway information. (F) miRNA _target sites. Due to the space limitation, only part of the content in each section is shown. Note that a gene (e.g. DTNBP1) may not have information in all categories.
Figure 4
Figure 4
Gene ranking and graphical presentation. (A) Online gene ranking tool. (B) Graphical presentation of rank positions of the core genes among all candidate genes. (C) Distribution of core and all genes by their scores.
See this image and copyright information in PMC

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