Mathematically defined tissue engineering scaffold architectures prepared by stereolithography
- PMID: 20579724
- DOI: 10.1016/j.biomaterials.2010.05.068
Mathematically defined tissue engineering scaffold architectures prepared by stereolithography
Abstract
The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(D,L-lactide)-based resin or a poly(D,L-lactide-co-epsilon-caprolactone)-based resin. Characterisation of the scaffolds by micro-computed tomography shows excellent reproduction of the designs. The mechanical properties are evaluated in compression, and show good agreement with finite element predictions. The mechanical properties of scaffolds can be controlled by the combination of material and scaffold pore architecture. The presented technology and materials enable an accurate preparation of tissue engineering scaffolds with a large freedom of design, and properties ranging from rigid and strong to highly flexible and elastic.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Design of porous three-dimensional PDLLA/nano-hap composite scaffolds using stereolithography.J Appl Biomater Funct Mater. 2012;10(3):249-58. doi: 10.5301/JABFM.2012.10211. J Appl Biomater Funct Mater. 2012. PMID: 23242874
-
Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography.Acta Biomater. 2011 Nov;7(11):3850-6. doi: 10.1016/j.actbio.2011.06.039. Epub 2011 Jun 27. Acta Biomater. 2011. PMID: 21763796
-
A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography.Biomaterials. 2009 Aug;30(23-24):3801-9. doi: 10.1016/j.biomaterials.2009.03.055. Epub 2009 Apr 29. Biomaterials. 2009. PMID: 19406467
-
Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS).Int J Mol Sci. 2021 Mar 28;22(7):3504. doi: 10.3390/ijms22073504. Int J Mol Sci. 2021. PMID: 33800709 Free PMC article. Review.
-
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering.Braz J Med Biol Res. 2014 Jul;47(7):533-9. doi: 10.1590/1414-431x20143930. Epub 2014 May 30. Braz J Med Biol Res. 2014. PMID: 25003631 Free PMC article. Review.
Cited by
-
Microfabricated biomaterials for engineering 3D tissues.Adv Mater. 2012 Apr 10;24(14):1782-804. doi: 10.1002/adma.201104631. Epub 2012 Mar 13. Adv Mater. 2012. PMID: 22410857 Free PMC article. Review.
-
Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.Biomed Res Int. 2015;2015:729076. doi: 10.1155/2015/729076. Epub 2015 Mar 26. Biomed Res Int. 2015. PMID: 25883972 Free PMC article. Review.
-
Composite bijel-templated hydrogels for cell delivery.ACS Biomater Sci Eng. 2018 Feb 12;4(2):587-594. doi: 10.1021/acsbiomaterials.7b00809. Epub 2018 Jan 18. ACS Biomater Sci Eng. 2018. PMID: 30555892 Free PMC article.
-
Is macroporosity absolutely required for preliminary in vitro bone biomaterial study? A comparison between porous materials and flat materials.J Funct Biomater. 2011 Nov 8;2(4):308-37. doi: 10.3390/jfb2040308. J Funct Biomater. 2011. PMID: 24956447 Free PMC article.
-
Effects of MgO nanoparticle addition on the mechanical properties, degradation properties, antibacterial properties and in vitro and in vivo biological properties of 3D-printed Zn scaffolds.Bioact Mater. 2024 Mar 16;37:72-85. doi: 10.1016/j.bioactmat.2024.03.016. eCollection 2024 Jul. Bioact Mater. 2024. PMID: 38523703 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
