Mathematically defined tissue engineering scaffold architectures prepared by stereolithography
- PMID: 20579724
- DOI: 10.1016/j.biomaterials.2010.05.068
Mathematically defined tissue engineering scaffold architectures prepared by stereolithography
Abstract
The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(D,L-lactide)-based resin or a poly(D,L-lactide-co-epsilon-caprolactone)-based resin. Characterisation of the scaffolds by micro-computed tomography shows excellent reproduction of the designs. The mechanical properties are evaluated in compression, and show good agreement with finite element predictions. The mechanical properties of scaffolds can be controlled by the combination of material and scaffold pore architecture. The presented technology and materials enable an accurate preparation of tissue engineering scaffolds with a large freedom of design, and properties ranging from rigid and strong to highly flexible and elastic.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Design of porous three-dimensional PDLLA/nano-hap composite scaffolds using stereolithography.J Appl Biomater Funct Mater. 2012;10(3):249-58. doi: 10.5301/JABFM.2012.10211. J Appl Biomater Funct Mater. 2012. PMID: 23242874
-
Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography.Acta Biomater. 2011 Nov;7(11):3850-6. doi: 10.1016/j.actbio.2011.06.039. Epub 2011 Jun 27. Acta Biomater. 2011. PMID: 21763796
-
A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography.Biomaterials. 2009 Aug;30(23-24):3801-9. doi: 10.1016/j.biomaterials.2009.03.055. Epub 2009 Apr 29. Biomaterials. 2009. PMID: 19406467
-
Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS).Int J Mol Sci. 2021 Mar 28;22(7):3504. doi: 10.3390/ijms22073504. Int J Mol Sci. 2021. PMID: 33800709 Free PMC article. Review.
-
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering.Braz J Med Biol Res. 2014 Jul;47(7):533-9. doi: 10.1590/1414-431x20143930. Epub 2014 May 30. Braz J Med Biol Res. 2014. PMID: 25003631 Free PMC article. Review.
Cited by
-
Review: Polymeric-Based 3D Printing for Tissue Engineering.J Med Biol Eng. 2015;35(3):285-292. doi: 10.1007/s40846-015-0038-3. Epub 2015 Jun 10. J Med Biol Eng. 2015. PMID: 26167139 Free PMC article.
-
Optimization Design and SLM Manufacturing of Porous Titanium Alloy Femoral Stem.Materials (Basel). 2024 Oct 6;17(19):4896. doi: 10.3390/ma17194896. Materials (Basel). 2024. PMID: 39410466 Free PMC article.
-
[Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Oct 25;38(5):960-968. doi: 10.7507/1001-5515.202102054. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021. PMID: 34713664 Free PMC article. Chinese.
-
Selective laser sintering fabrication of nano-hydroxyapatite/poly-ε-caprolactone scaffolds for bone tissue engineering applications.Int J Nanomedicine. 2013;8:4197-213. doi: 10.2147/IJN.S50685. Epub 2013 Nov 1. Int J Nanomedicine. 2013. PMID: 24204147 Free PMC article.
-
Scalable 3D printing of aperiodic cellular structures by rotational stacking of integral image formation.Sci Adv. 2021 Sep 17;7(38):eabh1200. doi: 10.1126/sciadv.abh1200. Epub 2021 Sep 17. Sci Adv. 2021. PMID: 34533994 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
