doi: 10.1016/j.cell.2010.11.016.
Will the ubiquitin system furnish as many drug _targets as protein kinases?
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- PMID: 21111230
- DOI: 10.1016/j.cell.2010.11.016
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Will the ubiquitin system furnish as many drug _targets as protein kinases?
Cell.
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Abstract
Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug _targets for the pharmaceutical industry. In contrast, drug discovery programs that _target components of the ubiquitin system have lagged behind. In this Perspective, we discuss the reasons for the delay in this pipeline, the drugs _targeting the ubiquitin system that have been developed, and new approaches that may popularize this area of drug discovery in the future.
Copyright © 2010 Elsevier Inc. All rights reserved.
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