Anti-diabetic effects of resveratrol
- PMID: 21261639
- DOI: 10.1111/j.1749-6632.2010.05844.x
Anti-diabetic effects of resveratrol
Abstract
Diabetes mellitus is a complex metabolic disease affecting about 5% of people all over the world. Data from the literature indicate that resveratrol is a compound exerting numerous beneficial effects in organisms. Rodent studies, for example, have demonstrated that resveratrol decreases blood glucose in animals with hyperglycemia. This effect seems to predominantly result from increased intracellular transport of glucose. Resveratrol was also demonstrated to induce effects that may contribute to the protection of β cells in diabetes. In experiments on pancreatic islets, the ability of resveratrol to reduce insulin secretion was demonstrated; this effect was confirmed in animals with hyperinsulinemia, in which resveratrol decreased blood insulin levels. Moreover, inhibition of cytokine action and attenuation of the oxidative damage of the pancreatic tissue by resveratrol were recently shown. Studies of animals with insulin resistance indicate that resveratrol may also improve insulin action. The mechanism through which resveratrol improves insulin action is complex and involves reduced adiposity, changes in gene expression, and changes in the activities of some enzymes. These data indicate that resveratrol may be useful in preventing and treating diabetes.
© 2011 New York Academy of Sciences.
Similar articles
-
Resveratrol and diabetes: from animal to human studies.Biochim Biophys Acta. 2015 Jun;1852(6):1145-54. doi: 10.1016/j.bbadis.2014.10.013. Epub 2014 Oct 27. Biochim Biophys Acta. 2015. PMID: 25445538 Review.
-
Protection of pancreatic beta-cells: is it feasible?Nutr Metab Cardiovasc Dis. 2008 Jan;18(1):74-83. doi: 10.1016/j.numecd.2007.05.004. Nutr Metab Cardiovasc Dis. 2008. PMID: 18096375 Review.
-
Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats.J Cell Physiol. 2010 Aug;224(2):423-32. doi: 10.1002/jcp.22138. J Cell Physiol. 2010. PMID: 20333650
-
Resveratrol and diabetes: A critical review of clinical studies.Biomed Pharmacother. 2017 Nov;95:230-234. doi: 10.1016/j.biopha.2017.08.070. Epub 2017 Sep 12. Biomed Pharmacother. 2017. PMID: 28843911 Review.
-
Resveratrol, obesity and diabetes.Eur J Pharmacol. 2010 Jun 10;635(1-3):1-8. doi: 10.1016/j.ejphar.2010.02.054. Epub 2010 Mar 19. Eur J Pharmacol. 2010. PMID: 20303945 Review.
Cited by
-
Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats.Genes Nutr. 2016 Oct 22;11:29. doi: 10.1186/s12263-016-0545-z. eCollection 2016. Genes Nutr. 2016. PMID: 27795741 Free PMC article.
-
Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.Biomed Res Int. 2014;2014:193095. doi: 10.1155/2014/193095. Epub 2014 Mar 5. Biomed Res Int. 2014. PMID: 24734227 Free PMC article. Review.
-
High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation.Mediators Inflamm. 2017;2017:9853108. doi: 10.1155/2017/9853108. Epub 2017 Jun 1. Mediators Inflamm. 2017. PMID: 28655972 Free PMC article.
-
Resveratrol and diabetes.Rev Diabet Stud. 2013 Winter;10(4):236-42. doi: 10.1900/RDS.2013.10.236. Epub 2014 Feb 10. Rev Diabet Stud. 2013. PMID: 24841877 Free PMC article. Review.
-
Chloroquine increases phosphorylation of AMPK and Akt in myotubes.Heliyon. 2016 Mar;2(3):e00083. doi: 10.1016/j.heliyon.2016.e00083. Heliyon. 2016. PMID: 27047993 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
