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. 2011 Sep;38(9):686-90.
doi: 10.1111/j.1365-2842.2011.02206.x. Epub 2011 Feb 17.

Fabrication of a multi-applicable removable intraoral denture system for rodent research

H Lee  1 , A Yu, C C Johnson, E A Lilly, M C Noverr, P L Fidel Jr
Affiliations

Fabrication of a multi-applicable removable intraoral denture system for rodent research

H Lee et al. J Oral Rehabil. 2011 Sep.

Abstract

The objective was to engineer an inexpensive intraoral removable denture system for rodents that can be utilised in numerous oral health research applications. At the forefront is biofilm research related to Candida-associated denture stomatitis. Previously described intraoral devices are primitive and inadequate. The denture system was engineered consisting of a fixed part that is anchored to the posterior palate by orthodontic wires and acrylic resin and a removable part fitted to the anterior palate that is retained by magnets embedded in the fixed part. Both parts are custom fitted to the rodent palate by impression making and cast fabrication. Rats fitted with the intraoral denture system maintained body weight and normal activity with the device maintaining integrity and durability for upwards of 8 weeks. The denture system was used successfully to establish a working model of denture stomatitis. This newly engineered inexpensive intraoral removable denture system for rodents can be utilised in numerous oral health research applications, including denture-associated infections, biofilms and a variety of biomaterial applications. The removable portion is advantageous for longitudinal analyses and charging/discharging of biomaterials.

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Figures

Figure 1
Figure 1
Figure 1A. Taking an impression. Impression of the maxillary arch was done using vinyl polysiloxane impression material and wooden tongue depressor. Figure 1B. Creating a stone cast. A stone cast was made with two magnets embedded and a metal bar placed and secured using wax. Figure 1C. The finished device on cast. The finished cast with the fixed portion devoid of covering the occlusal surface of cheek teeth.
Figure 1
Figure 1
Figure 1A. Taking an impression. Impression of the maxillary arch was done using vinyl polysiloxane impression material and wooden tongue depressor. Figure 1B. Creating a stone cast. A stone cast was made with two magnets embedded and a metal bar placed and secured using wax. Figure 1C. The finished device on cast. The finished cast with the fixed portion devoid of covering the occlusal surface of cheek teeth.
Figure 1
Figure 1
Figure 1A. Taking an impression. Impression of the maxillary arch was done using vinyl polysiloxane impression material and wooden tongue depressor. Figure 1B. Creating a stone cast. A stone cast was made with two magnets embedded and a metal bar placed and secured using wax. Figure 1C. The finished device on cast. The finished cast with the fixed portion devoid of covering the occlusal surface of cheek teeth.
Figure 2
Figure 2
Orthodontic ligature wires used for scaffold support. Placement of orthodontic ligature wire on the right and left interproximal spaces between the first and second cheek tooth
Figure 3
Figure 3
Installed removable intraoral device. The complete device shown as installed on the rat palate
Figure 4
Figure 4
Monitoring of rat activity. Change in body weight of rats with removable intraoral device over a 4 week period.
See this image and copyright information in PMC

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