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Randomized Controlled Trial
. 2012 Oct;51(7):841-50.
doi: 10.1007/s00394-011-0264-6. Epub 2011 Oct 25.

Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content

Stephan W Barth  1 , Tatiana C L Koch, Bernhard Watzl, Helmut Dietrich, Frank Will, Achim Bub
Affiliations
Randomized Controlled Trial

Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content

Stephan W Barth et al. Eur J Nutr. 2012 Oct.

Abstract

Purpose: The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.

Methods: In this controlled, randomized, and parallel study, n = 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m(2) received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.

Results: CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: -1.0 ± 1.3 vs. CB: -0.2 ± 0.9, p < 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable.

Conclusion: The observed diet-gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.

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References

    1. BMC Public Health. 2008 Jun 05;8:200 - PubMed
    1. J Oleo Sci. 2007;56(8):417-28 - PubMed
    1. J Agric Food Chem. 2007 Oct 17;55(21):8404-10 - PubMed
    1. Obesity (Silver Spring). 2008 Mar;16(3):710-3 - PubMed
    1. Ann N Y Acad Sci. 2007 Nov;1119:196-202 - PubMed

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