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doi: 10.1016/j.cell.2011.10.028.
PINK1 and Parkin flag Miro to direct mitochondrial traffic
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- PMID: 22078873
- DOI: 10.1016/j.cell.2011.10.028
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PINK1 and Parkin flag Miro to direct mitochondrial traffic
Cell.
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Abstract
The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, _targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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PINK1 and Parkin _target Miro for phosphorylation and degradation to arrest mitochondrial motility.Cell. 2011 Nov 11;147(4):893-906. doi: 10.1016/j.cell.2011.10.018. Cell. 2011. PMID: 22078885 Free PMC article.
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