Peripheral mechanisms of itch

doi:10.1007/s12264-012-1202-1

Review

. 2012 Apr;28(2):100-10.

doi: 10.1007/s12264-012-1202-1.

Peripheral mechanisms of itch

Benjamin McNeil¹, Xinzhong Dong

Affiliations

PMID: 22466121
PMCID: PMC5560392
DOI: 10.1007/s12264-012-1202-1

Review

Peripheral mechanisms of itch

Benjamin McNeil et al. Neurosci Bull. 2012 Apr.

. 2012 Apr;28(2):100-10.

doi: 10.1007/s12264-012-1202-1.

Authors

Benjamin McNeil¹, Xinzhong Dong

Affiliation

¹ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

PMID: 22466121
PMCID: PMC5560392
DOI: 10.1007/s12264-012-1202-1

Abstract

Detection of environmental stimuli that provoke an aversive response has been shown to involve many receptors in the periphery. Probably the least-studied of these stimuli are those that induce the perception of itch (pruritus), an often-experienced unpleasant stimulus. This review covers the ligands and their receptors which are known to cause primary sensory neuron activation and initiate itch sensation. Also covered are several itch-inducing substances which may act indirectly by activating other cell types in the periphery which then signal to primary neurons. Finally, progress in identifying candidate neurotransmitters that sensory neurons use to propagate the itch signal is discussed.

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References

1. Sun Y.G., Chen Z.F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature. 2007;448:700–703. doi: 10.1038/nature06029. - DOI - PubMed
1. Sun Y.G., Zhao Z.Q., Meng X.L., Yin J., Liu X.Y., Chen Z.F. Cellular basis of itch sensation. Science. 2009;325:1531–1534. doi: 10.1126/science.1174868. - DOI - PMC - PubMed
1. Schmelz M., Schmidt R., Bickel A., Handwerker H.O., Torebjork H.E. Specific C-receptors for itch in human skin. J Neurosci. 1997;17:8003–8008. - PMC - PubMed
1. Schmelz M., Schmidt R., Weidner C., Hilliges M., Torebjork H.E., Handwerker H.O. Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol. 2003;89:2441–2448. doi: 10.1152/jn.01139.2002. - DOI - PubMed
1. Johanek L.M., Meyer R.A., Hartke T., Hobelmann J.G., Maine D.N., LaMotte R.H., et al. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci. 2007;27:7490–7497. doi: 10.1523/JNEUROSCI.1249-07.2007. - DOI - PMC - PubMed

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[1] Sun Y.G., Chen Z.F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature. 2007;448:700–703. doi: 10.1038/nature06029. - DOI - PubMed

[2] Sun Y.G., Chen Z.F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature. 2007;448:700–703. doi: 10.1038/nature06029. - DOI - PubMed

[3] Sun Y.G., Zhao Z.Q., Meng X.L., Yin J., Liu X.Y., Chen Z.F. Cellular basis of itch sensation. Science. 2009;325:1531–1534. doi: 10.1126/science.1174868. - DOI - PMC - PubMed

[4] Sun Y.G., Zhao Z.Q., Meng X.L., Yin J., Liu X.Y., Chen Z.F. Cellular basis of itch sensation. Science. 2009;325:1531–1534. doi: 10.1126/science.1174868. - DOI - PMC - PubMed

[5] Schmelz M., Schmidt R., Bickel A., Handwerker H.O., Torebjork H.E. Specific C-receptors for itch in human skin. J Neurosci. 1997;17:8003–8008. - PMC - PubMed

[6] Schmelz M., Schmidt R., Bickel A., Handwerker H.O., Torebjork H.E. Specific C-receptors for itch in human skin. J Neurosci. 1997;17:8003–8008. - PMC - PubMed

[7] Schmelz M., Schmidt R., Weidner C., Hilliges M., Torebjork H.E., Handwerker H.O. Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol. 2003;89:2441–2448. doi: 10.1152/jn.01139.2002. - DOI - PubMed

[8] Schmelz M., Schmidt R., Weidner C., Hilliges M., Torebjork H.E., Handwerker H.O. Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol. 2003;89:2441–2448. doi: 10.1152/jn.01139.2002. - DOI - PubMed

[9] Johanek L.M., Meyer R.A., Hartke T., Hobelmann J.G., Maine D.N., LaMotte R.H., et al. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci. 2007;27:7490–7497. doi: 10.1523/JNEUROSCI.1249-07.2007. - DOI - PMC - PubMed

[10] Johanek L.M., Meyer R.A., Hartke T., Hobelmann J.G., Maine D.N., LaMotte R.H., et al. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci. 2007;27:7490–7497. doi: 10.1523/JNEUROSCI.1249-07.2007. - DOI - PMC - PubMed

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Peripheral mechanisms of itch

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Peripheral mechanisms of itch

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