Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;37(4):301-7.
doi: 10.1007/s13318-012-0092-y. Epub 2012 Apr 24.

Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine

Ivana Vapa  1 , Vukosava Milic Torres, Aleksandar Djordjevic, Velibor Vasovic, Branislava Srdjenovic, Viktorija Dragojevic Simic, Jovan K Popović
Affiliations

Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine

Ivana Vapa et al. Eur J Drug Metab Pharmacokinet. 2012 Dec.

Abstract

The aim of this study is to investigate the protective effect of fullerenol C₆₀(OH)₂₄ in various doses, on lipid peroxidation of rat's kidneys, testes and lungs after application of doxorubicin. The experiment was performed on healthy male Wistar rats. The animals were randomly divided into five experimental groups and treated with saline (0.9 % NaCl i.v.), doxorubicin alone (10 mg/kg i.v.), combination of doxorubicin/fullerenol (50 and 100 mg/kg fullerenol, respectively, 30 min before the introduction of doxorubicin) and fullerenol alone (100 mg/kg), respectively. Animals were killed on the 2nd and 14th day after treatment. Products of lipid peroxidation and thiobarbituric acid are determined spectrophotometrically from the crude homogenate fraction of the kidney, testis and lung tissues of the rats. Fullerenol, applied as a pre-treatment of doxorubicin, significantly reduced or completely prevented the appearance of doxorubicin toxicity in kidneys and testes, in both tested doses. A dose of 100 mg/kg i.p. exhibited a better protective effect. When fullerenol was applied alone, at a dose of 100 mg/kg i.p, it did not significantly affect the intensity of lipid peroxidation in all tested organs.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. PLoS One. 2011;6(5):e19976 - PubMed
    1. Nephrol Dial Transplant. 1998 Aug;13(8):1975-9 - PubMed
    1. Toxicol In Vitro. 2004 Oct;18(5):629-37 - PubMed
    1. Life Sci. 2003 Jan 31;72(11):1271-8 - PubMed
    1. Am J Respir Crit Care Med. 2005 Aug 15;172(4):417-22 - PubMed

LinkOut - more resources

  NODES
admin 1
twitter 2