Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

doi:10.1016/j.ypmed.2012.04.009

Multicenter Study

. 2012 Jun;54(6):434-9.

doi: 10.1016/j.ypmed.2012.04.009. Epub 2012 Apr 23.

Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

Pere Godoy¹, Jesús Castilla, Miguel Delgado-Rodríguez, Vicente Martín, Núria Soldevila, Jordi Alonso, Jenaro Astray, Maretva Baricot, Rafael Cantón, Ady Castro, Fernando González-Candelas, José María Mayoral, José María Quintana, Tomás Pumarola, Sonia Tamames, Angela Domínguez; CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain

Collaborators, Affiliations

Collaborators

CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain:
E Azor, J Carrillo, R Moyano, J A Navarro, M Vázquez, F Zafra, M A Bueno, M L Gómez, M Mariscal, B Martínez, J P Quesada, M Sillero, M Carnero, J Fernández-Crehuet, J del Diego Salas, V Fuentes, V Gallardo, E Pérez, R López, J R Maldonado, A Morillo, J M Navarro, M Pérez, S Oña, M J Pérez, M C Ubago, M Zarzuela, J Blanquer, M Morales, D Carriedo, F Díez, I Fernández, S Fernandez, M P Sanz, J J Castrodeza, A Pérez, R Ortiz de Lejarazu, J Ortiz, A Pueyo, J L Viejo, P Redondo, A Molina, A Agustí, A Vilella, Arnau de Vilanova, L Blanch, G Navarro, X Bonfill, J López-Contreras, V Pomar, M T Puig, E Borràs, A Martínez, N Torner, C Bravo, F Moraga, F Calafell, J Caylà, I Garcia, J Ruiz, J J García, Sant Joan de Deu, O Garín, J Gea, J P Horcajada, N Hayes, A Rosell, C Álvarez, M Enríquez, F Pozo, F Baquero, J C Galán, A Robustillo, E Córdoba, F Dominguez, J García, R Génova, Elisa Gil, S Jiménez, M A Lopaz, J López, F Martín, M L Martínez, M Ordobás, E Rodriguez, S Sánchez, C Valdés, J R Paño, M Romero, A Martinez, L Martínez, M Ruiz, P Fanlo, F Gil, V Martínez-Artola, M E Ursua, M Sota, M T Virto, J Gamboa, F Pérez-Afonso, U Aguirre, A Caspelastegui, P P España, S García, J M Antoñana, I Astigarraga, J I Pijoan, I Pocheville, M Santiago, J I Villate, J Arístegui, A Escobar, M I Garrote, A Bilbao, C Garaizar, G Cilla, J Korta, E Pérez Trallero, C Sarasqueta, F Esteban, C Salado, J L Lobo, J Alustizac, A Torres, A Trilla, C Tortajada

Affiliation

¹ Departament de Salut, Generalitat of Catalonia, Spain. Pere.godoy@gencat.cat

PMID: 22548868
PMCID: PMC7119305
DOI: 10.1016/j.ypmed.2012.04.009

Multicenter Study

Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

Pere Godoy et al. Prev Med. 2012 Jun.

. 2012 Jun;54(6):434-9.

doi: 10.1016/j.ypmed.2012.04.009. Epub 2012 Apr 23.

Authors

Collaborators

CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain:
E Azor, J Carrillo, R Moyano, J A Navarro, M Vázquez, F Zafra, M A Bueno, M L Gómez, M Mariscal, B Martínez, J P Quesada, M Sillero, M Carnero, J Fernández-Crehuet, J del Diego Salas, V Fuentes, V Gallardo, E Pérez, R López, J R Maldonado, A Morillo, J M Navarro, M Pérez, S Oña, M J Pérez, M C Ubago, M Zarzuela, J Blanquer, M Morales, D Carriedo, F Díez, I Fernández, S Fernandez, M P Sanz, J J Castrodeza, A Pérez, R Ortiz de Lejarazu, J Ortiz, A Pueyo, J L Viejo, P Redondo, A Molina, A Agustí, A Vilella, Arnau de Vilanova, L Blanch, G Navarro, X Bonfill, J López-Contreras, V Pomar, M T Puig, E Borràs, A Martínez, N Torner, C Bravo, F Moraga, F Calafell, J Caylà, I Garcia, J Ruiz, J J García, Sant Joan de Deu, O Garín, J Gea, J P Horcajada, N Hayes, A Rosell, C Álvarez, M Enríquez, F Pozo, F Baquero, J C Galán, A Robustillo, E Córdoba, F Dominguez, J García, R Génova, Elisa Gil, S Jiménez, M A Lopaz, J López, F Martín, M L Martínez, M Ordobás, E Rodriguez, S Sánchez, C Valdés, J R Paño, M Romero, A Martinez, L Martínez, M Ruiz, P Fanlo, F Gil, V Martínez-Artola, M E Ursua, M Sota, M T Virto, J Gamboa, F Pérez-Afonso, U Aguirre, A Caspelastegui, P P España, S García, J M Antoñana, I Astigarraga, J I Pijoan, I Pocheville, M Santiago, J I Villate, J Arístegui, A Escobar, M I Garrote, A Bilbao, C Garaizar, G Cilla, J Korta, E Pérez Trallero, C Sarasqueta, F Esteban, C Salado, J L Lobo, J Alustizac, A Torres, A Trilla, C Tortajada

Affiliation

¹ Departament de Salut, Generalitat of Catalonia, Spain. Pere.godoy@gencat.cat

PMID: 22548868
PMCID: PMC7119305
DOI: 10.1016/j.ypmed.2012.04.009

Abstract

Background: The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization.

Methods: We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected.

Results: We studied 813 cases hospitalized for influenza and 2274 controls. The frequency of hand washing 5-10 times (adjusted odds ratio [aOR]=0.65) and >10 times (aOR=0.59) and handwashing after contact with contaminated surfaces (aOR=0.65) were protective factors and were dose-responsive (p<0.001). Alcohol-based hand sanitizers were associated with marginal benefits (aOR=0.82).

Conclusions: Frequent handwashing should be recommended to prevent influenza cases requiring hospitalization.

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References

1. Aiello A.E., Murray G.F., Perez V. Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J. Infect. Dis. 2010;201:491–498. - PubMed
1. Ansari S., Sattar S., Springthorpe V., Wells G., Tostowaryk W. In vivo protocol for testing efficacy of hand-washing agents against viruses and bacteria: experiments with rotavirus and Escherichia coli. Appl. Environ. Microbiol. 1989;55:3113. - PMC - PubMed
1. Bean B., Moore B., Sterner B., Peterson L., Gerding D., Balfour H. Survival of influenza viruses on environmental surfaces. J. Infect. Dis. 1982;146:47. - PubMed
1. Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg. Infect. Dis. 2006;12:81–87. - PMC - PubMed
1. Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, national and community measures. Emerg. Infect. Dis. 2006;12:88–94. - PMC - PubMed

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[1] Aiello A.E., Murray G.F., Perez V. Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J. Infect. Dis. 2010;201:491–498. - PubMed

[2] Aiello A.E., Murray G.F., Perez V. Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J. Infect. Dis. 2010;201:491–498. - PubMed

[3] Ansari S., Sattar S., Springthorpe V., Wells G., Tostowaryk W. In vivo protocol for testing efficacy of hand-washing agents against viruses and bacteria: experiments with rotavirus and Escherichia coli. Appl. Environ. Microbiol. 1989;55:3113. - PMC - PubMed

[4] Ansari S., Sattar S., Springthorpe V., Wells G., Tostowaryk W. In vivo protocol for testing efficacy of hand-washing agents against viruses and bacteria: experiments with rotavirus and Escherichia coli. Appl. Environ. Microbiol. 1989;55:3113. - PMC - PubMed

[5] Bean B., Moore B., Sterner B., Peterson L., Gerding D., Balfour H. Survival of influenza viruses on environmental surfaces. J. Infect. Dis. 1982;146:47. - PubMed

[6] Bean B., Moore B., Sterner B., Peterson L., Gerding D., Balfour H. Survival of influenza viruses on environmental surfaces. J. Infect. Dis. 1982;146:47. - PubMed

[7] Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg. Infect. Dis. 2006;12:81–87. - PMC - PubMed

[8] Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg. Infect. Dis. 2006;12:81–87. - PMC - PubMed

[9] Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, national and community measures. Emerg. Infect. Dis. 2006;12:88–94. - PMC - PubMed

[10] Bell D.M., World Health Organization Writing Group Non-pharmaceutical interventions for pandemic influenza, national and community measures. Emerg. Infect. Dis. 2006;12:88–94. - PMC - PubMed

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Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

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Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

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