Comment
doi: 10.1161/CIRCRESAHA.112.275867.
Inflame on!: mitochondrial escape provokes cytokine storms that doom the heart
- PMID: 22821906
- DOI: 10.1161/CIRCRESAHA.112.275867
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Inflame on!: mitochondrial escape provokes cytokine storms that doom the heart
Circ Res.
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Abstract
Mitochondria are derived from primordial bacterial endosymbionts and retain partial genomes. In mammalian cells, damaged or dysfunctional mitochondria are recognized, _targeted for elimination, then neatly packaged and eliminated via mitophagy. A recent paper from Oka et al describes how interrupting normal mitophagic mitochondrial DNA degradation after pressure overload can activate Toll-like receptor-9 mediated innate immunity, causing myocardial inflammation that contributes to cardiomyopathic decompensation.
Comment on
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.Nature. 2012 May 10;485(7397):251-5. doi: 10.1038/nature10992. Nature. 2012. PMID: 22535248 Free PMC article.
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