Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2012 Dec;33(6):2041-51.
doi: 10.1007/s13277-012-0463-7. Epub 2012 Aug 15.

Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians

Shan Zhong  1 , Jia-He Yang, Kai Liu, B H Jiao, Zhi-Jie Chang
Affiliations
Meta-Analysis

Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians

Shan Zhong et al. Tumour Biol. 2012 Dec.

Abstract

A great number of studies regarding the association between MTHFR C677T polymorphism and risk of colorectal cancer (CRC) in East Asians were published, but the results were inconsistent. Thus, a meta-analysis was performed to investigate the association. PubMed, Embase, and CBM databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were calculated using random or fixed effect models. Finally, 24 case-control studies with a total of 7,230 CRC cases and 9,285 controls were included. Meta-analyses of a total of 24 studies showed there was a statistically significant association between MTHFR C677T polymorphism and decreased CRC risk in East Asians under four genetic models (T versus C, OR = 0.92, 95 % CI 0.85-0.99; TT versus CC, OR = 0.80, 95 % CI 0.69-0.94; TT versus CT/CC, OR = 0.82, 95 % CI 0.71-0.95; TT/CT versus CC, OR = 0.92, 95 % CI 0.86-0.98). The cumulative meta-analyses for the allele contrast (T versus C), homozygote (TT versus CC), dominant (TT/CT versus CC), and recessive (TT versus CT/CC) models all showed a trend of more obvious association as information accumulated by year. Subgroup analyses by country further identified this association in Korea and Japan. This meta-analysis suggests that MTHFR C677T polymorphism is associated with decreased risk of colorectal cancer in East Asians, and MTHFR 677T variant has a protective effect on colorectal cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Hum Genet. 2007;52(1):73-85 - PubMed
    1. J Clin Epidemiol. 2003 Apr;56(4):297-303 - PubMed
    1. Diagn Pathol. 2009 Nov 24;4:39 - PubMed
    1. Mol Biol Rep. 2012 May;39(5):6203-11 - PubMed
    1. Stat Med. 2002 Jun 15;21(11):1559-73 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

  NODES
Association 13
twitter 2