Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions
- PMID: 22972022
- DOI: 10.1507/endocrj.ej12-0134
Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions
Abstract
Hypogonadotropic hypogonadism is defined as the failure in production of gonadal hormones, thus resulting in lower amounts of testosterone. Depression, anxiety and decreased quality of life are the most common psychopathological conditions in young hypogonadal men. The aim of the present study was to assess the still debated relationship with testosterone levels and psychological symptoms in young male patients with congenital hypogonadotropic hypogonadism (CHH). Thirty-nine young male patients with CHH and 40 age-matched healthy males were enrolled in the present study. The impact of testosterone replacement treatment (TRT) on the patients' anxiety and depression levels, sexual function and quality of life were assessed before and after 6 months of treatment using valid and reliable scales, including the Short Form-36 (SF-36), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Arizona Sexual Experiences (ASEX). Patients with CHH had significantly higher scores for BDI, BAI, and ASEX than the control subjects at baseline (p=0.011, p=0.036, p<0.001, respectively). The ASEX and BDI scores significantly improved after the TRT (p<0.001 for both), while the improvement in the BAI score was not statistically significant (p=0.135). When compared to the control group, treatment naïve hypogonadal patients had more severe symptoms of sexual dysfunction, anxiety, depression, and worse quality of life. After 6 months of TRT, we observed improvements in the above parameters, suggesting that low endogenous levels of testosterone might be related to the increased incidence of psychological symptoms.
Similar articles
-
Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME).J Sex Med. 2017 Sep;14(9):1104-1115. doi: 10.1016/j.jsxm.2017.07.004. Epub 2017 Aug 7. J Sex Med. 2017. PMID: 28781213 Clinical Trial.
-
Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea.Aging Male. 2018 Jun;21(2):99-105. doi: 10.1080/13685538.2017.1378320. Epub 2017 Sep 18. Aging Male. 2018. PMID: 28920756 Clinical Trial.
-
Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes.J Sex Med. 2013 Jun;10(6):1612-27. doi: 10.1111/jsm.12146. Epub 2013 Apr 3. J Sex Med. 2013. PMID: 23551886 Clinical Trial.
-
The association of hypogonadism with depression and its treatments.Front Endocrinol (Lausanne). 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37635965 Free PMC article. Review.
-
Patients with testosterone deficit syndrome and depression.Arch Esp Urol. 2013 Sep;66(7):729-36. Arch Esp Urol. 2013. PMID: 24047633 Review.
Cited by
-
The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men.Rev Endocr Metab Disord. 2022 Dec;23(6):1259-1273. doi: 10.1007/s11154-022-09767-0. Epub 2022 Nov 22. Rev Endocr Metab Disord. 2022. PMID: 36418656 Free PMC article. Review.
-
Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial.PLoS Med. 2019 Nov 12;16(11):e1002960. doi: 10.1371/journal.pmed.1002960. eCollection 2019 Nov. PLoS Med. 2019. PMID: 31714912 Free PMC article. Clinical Trial.
-
Sex Differences in Affective Dysfunction and Alterations in Parvalbumin in Rodent Models of Early Life Adversity.Front Behav Neurosci. 2021 Nov 4;15:741454. doi: 10.3389/fnbeh.2021.741454. eCollection 2021. Front Behav Neurosci. 2021. PMID: 34803622 Free PMC article. Review.
-
FSHR ablation induces depression-like behaviors.Acta Pharmacol Sin. 2020 Aug;41(8):1033-1040. doi: 10.1038/s41401-020-0384-8. Epub 2020 Mar 18. Acta Pharmacol Sin. 2020. PMID: 32203083 Free PMC article.
-
Reduced Quality of Life and Sexual Satisfaction in Isolated Hypogonadotropic Hypogonadism.J Clin Med. 2021 Jun 14;10(12):2622. doi: 10.3390/jcm10122622. J Clin Med. 2021. PMID: 34198686 Free PMC article.
