doi: 10.1126/science.2305264.
Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant
Affiliations
- PMID: 2305264
- DOI: 10.1126/science.2305264
Item in Clipboard
Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant
Science.
.
Abstract
A founder transgenic mouse harbored two different integration patterns of a transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were allelic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development.
Similar articles
-
Mini-mouse: phenotypic characterization of a transgenic insertional mutant allelic to pygmy.Genet Res. 1994 Aug;64(1):27-33. doi: 10.1017/s0016672300032511. Genet Res. 1994. PMID: 7958830
-
Analysis of the hotfoot (ho) locus by creation of an insertional mutation in a transgenic mouse.Dev Biol. 1990 Feb;137(2):349-58. doi: 10.1016/0012-1606(90)90259-l. Dev Biol. 1990. PMID: 1689261
-
Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis.Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20. doi: 10.1073/pnas.87.13.5016. Proc Natl Acad Sci U S A. 1990. PMID: 2164218 Free PMC article.
-
Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure.Int J Dev Biol. 1998;42(7):1009-17. Int J Dev Biol. 1998. PMID: 9853832 Review.
-
Calorie restriction and dwarf mice in gerontological research.Gerontology. 2010;56(4):404-9. doi: 10.1159/000235720. Epub 2009 Aug 19. Gerontology. 2010. PMID: 19690401 Review.
Cited by
-
Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice.Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8787-91. doi: 10.1073/pnas.88.19.8787. Proc Natl Acad Sci U S A. 1991. PMID: 1924340 Free PMC article.
-
Warner-Lambert/Parke-Davis Award lecture. Many tumors and many genes: genetics of uterine leiomyomata.Am J Pathol. 1998 Oct;153(4):1015-20. doi: 10.1016/s0002-9440(10)65645-3. Am J Pathol. 1998. PMID: 9777932 Free PMC article. Review. No abstract available.
-
A DNA insertional mutation results in microphthalmia in transgenic mice.Transgenic Res. 1993 Jan;2(1):14-20. doi: 10.1007/BF01977676. Transgenic Res. 1993. PMID: 8513335
-
Binding to the Other Side: The AT-Hook DNA-Binding Domain Allows Nuclear Factors to Exploit the DNA Minor Groove.Int J Mol Sci. 2024 Aug 14;25(16):8863. doi: 10.3390/ijms25168863. Int J Mol Sci. 2024. PMID: 39201549 Free PMC article. Review.
-
Inherited haemolytic anaemia created by insertional inactivation of the alpha-spectrin gene.Transgenic Res. 1992 Nov;1(6):268-74. doi: 10.1007/BF02525168. Transgenic Res. 1992. PMID: 1338695
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
