Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 May;53(5):549-53.

Primary cutaneous undifferentiated round cell tumor with concurrent polymyositis in a dog

Paola Gianella  1 , Giancarlo Avallone, Claudio Bellino, Selina Iussich, Chiara Palmieri, Paola Roccabianca, Claudia Salvadori, Renato Zanatta, Antonio D'Angelo
Affiliations
Case Reports

Primary cutaneous undifferentiated round cell tumor with concurrent polymyositis in a dog

Paola Gianella et al. Can Vet J. 2012 May.

Abstract
in English, French

A cutaneous poorly differentiated round cell tumor with concurrent, non-suppurative, polymyositis was diagnosed in a hovawart dog. Histochemical staining, immunohistochemistry, and transmission electron microscopy findings suggested that the tumors cells were of myeloid, or possibly natural killer cell origin. The possibility that the concurrent polymyositis may represent a pre-neoplastic or paraneoplastic process is discussed.

Tumeur cutanée primaire indifférenciée à cellules rondes avec polymyosite concomitante chez un chien. Une tumeur cutanée à cellules rondes mal différenciée avec polymyosite non suppurative concomitante a été diagnostiquée chez un chien Hovawart. Les résultats de la coloration histochimique, de l’immunohistochimie et de la microscopie électronique à transmission ont suggéré que les cellules de la tumeur étaient d’origine myéloïde ou possiblement des cellules tueuses naturelles. La possibilité que la polymyosite concomitante puisse représenter un processus néoplasique ou paranéoplasique est examinée.

(Traduit par Isabelle Vallières)

PubMed Disclaimer

Figures

Figure 1
Figure 1
Ulcerated cutaneous lesion caudal to the left scapula.
Figure 2
Figure 2
Section of the cranial tibial muscle. There are endomysial inflammatory infiltrates composed of macrophages, lymphocytes and rare neutrophils, associated with phagocytosis of non-necrotic fibers and myonecrosis (H&E, Bar = 100 μm).
Figure 3
Figure 3
Haired skin, deep dermis: multifocal aggregates of round neoplastic cells invading vascular walls and associated with microhemorrhages and necrosis (H&E, Bar = 50 μm).
Figure 4
Figure 4
Ulcerated lesions of the preputial skin and glans penis.
Figure 5
Figure 5
Electron micrograph of a skin biopsy: note the electron-dense granules (arrow) and rough endoplasmic reticulum (arrowhead) within the cytoplasm of a neoplastic cells (Uranyl acetate and lead citrate, Bar = 0.3 μm).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Fu B, Wang F, Sun R, Ling B, Tian Z, Wei H. CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells. Immunology. 2011;133:350–359. - PMC - PubMed
    1. Kaddu S, Beham-Schmid C, Zenahlik P, Kerl H, Cerroni L. CD56+ blastic transformation of chronic myeloid leukemia involving the skin. J Cutan Pathol. 1999;26:497–503. - PubMed
    1. Kaddu S, Zenahlik P, Beham-Schmid C, Kerl H, Cerroni L. Specific cutaneous infiltrates in patients with myelogenous leukemia: A clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol. 1999;4:966–978. - PubMed
    1. Soutou B, Aractingi S. Myeloproliferative disorder therapy: Assessment and management of adverse events — a dermatologist’s perspective. Hematol. 2009;27:11–13. - PubMed
    1. Wiechert A, Reinhard G, Tüting T, Uerlich M, Bieber T, Wenzel J. Multiple skin cancers in a patient treated with hydroxyurea. Hautarzt. 2009;60:651–652. 654. - PubMed

Publication types

LinkOut - more resources

  NODES
Note 2
twitter 2