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Review
. 2013 Apr;21(4):167-73.
doi: 10.1016/j.tim.2012.12.001. Epub 2013 Jan 14.

Development of intestinal microbiota in infants and its impact on health

Sebastien Matamoros  1 , Christele Gras-Leguen, Françoise Le Vacon, Gilles Potel, Marie-France de La Cochetiere
Affiliations
Review

Development of intestinal microbiota in infants and its impact on health

Sebastien Matamoros et al. Trends Microbiol. 2013 Apr.

Abstract

Throughout the human lifetime, the intestinal microbiota performs vital functions, such as barrier function, metabolic reactions, trophic effects, and maturation of the host's innate and adaptive immune responses. Development of the intestinal microbiota in infants is characterized by rapid and large changes in microbial abundance, diversity, and composition. These changes are influenced by medical, cultural, and environmental factors such as mode of delivery, diet, familial environment, diseases, and therapies used. Thus, it is nearly impossible to define a universal standard for intestinal colonization and development of the intestinal microbiota. This review discusses recent data on the early colonization of the gut by microbial species, development of the intestinal microbiota, and its impact on health.

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