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. 2013 Sep;24(9):1737-46.
doi: 10.1007/s10552-013-0251-8. Epub 2013 Jun 29.

A large prospective study of risk factors for adenocarcinomas and malignant carcinoid tumors of the small intestine

Amanda J Cross  1 , Albert R Hollenbeck, Yikyung Park
Affiliations

A large prospective study of risk factors for adenocarcinomas and malignant carcinoid tumors of the small intestine

Amanda J Cross et al. Cancer Causes Control. 2013 Sep.

Abstract

Purpose: Small intestinal cancer is increasing in the U.S.A, yet little is known about its etiology. Our aim was to prospectively evaluate risk factors for this malignancy by the two main histologic subtypes (adenocarcinomas and carcinoids).

Methods: Hazard ratios and 95% confidence intervals (CI) were estimated for all incident small intestinal cancers (n = 237), adenocarcinomas (n = 84), and malignant carcinoids (n = 124), by demographic and lifestyle factors among 498,376 men and women.

Results: Age was the only risk factor for adenocarcinomas (HR for ≥ 65 vs. 50-55 years = 3.12, 95% CI 1.33, 7.31). Age (HR for ≥ 65 vs. 50-55 years = 3.31, 95% CI 1.51, 7.28), male sex (HR = 1.44, 95% CI 1.01, 2.05), body mass index (BMI, HR for ≥ 35 vs. 18.5-< 25 kg/m2 = 1.95, 95% CI 1.06, 3.58), and current menopausal hormone therapy use (HR = 1.94, 95% CI 1.07, 3.50) were positively associated with malignant carcinoids. A family history of any cancer or colorectal cancer (HR = 1.42, 95% CI 0.99, 2.03; 1.61, 0.97, 2.65, respectively), or a personal history of colorectal polyps (HR = 1.51, 95% CI 0.92, 2.46) produced elevated, but not statistically significant, risks for malignant carcinoids. Race, education, diabetes, smoking, physical activity, and alcohol intake were not associated with either histologic subtype.

Conclusions: Risk factors differed according to cancer subtype; only age was associated with adenocarcinomas, whereas age, male sex, BMI, and menopausal hormone therapy use were positively associated with malignant carcinoids.

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References

    1. Parkin DM, Whelan SL, Ferlay J, Teppo DB. Cancer Incidence in Five Continents. VIII. IARC Scientific Publications; Lyon, France: 2002.
    1. Ries LAG, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, Hayat M, Hankey BF, Edwards BK. SEER Cancer Statistics Review, 1975-2003. National Cancer Institute; Bethesda, MD: 2006. http://seer.cancer.gov/csr/1975_2003/

    1. Howlader NNA, Krapcho M, Garshell J, Neyman N, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA, editors. SEER Cancer Statistics Review, 1975-2010. National Cancer Institute; Bethesda, MD: http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, 2013.

    1. Scelo G, Boffetta P, Hemminki K, Pukkala E, Olsen JH, Andersen A, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Chia KS, Jonasson JG, Martos C, Colin D, Brennan P. Associations between small intestine cancer and other primary cancers: an international population-based study. Int J Cancer. 2006;118:189–96. - PubMed
    1. Schottenfeld D, Fraumeni JF. Cancer Epidemiology and Prevention. Oxford University Press; New York: 2006.

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