Glial influence on the blood brain barrier
- PMID: 24123158
- PMCID: PMC4068281
- DOI: 10.1002/glia.22575
Glial influence on the blood brain barrier
Abstract
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.
Keywords: BBB; astrocyte; astrogliosis; glial; multiple sclerosis.
Copyright © 2013 Wiley Periodicals, Inc.
Figures
Similar articles
-
Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes.Diabetes Metab J. 2022 Mar;46(2):222-238. doi: 10.4093/dmj.2021.0146. Epub 2022 Mar 18. Diabetes Metab J. 2022. PMID: 35299293 Free PMC article. Review.
-
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.Proteomics. 2013 Apr;13(7):1185-99. doi: 10.1002/pmic.201200166. Proteomics. 2013. PMID: 23436736
-
Morphofunctional aspects of the blood-brain barrier.Curr Drug Metab. 2012 Jan;13(1):50-60. doi: 10.2174/138920012798356970. Curr Drug Metab. 2012. PMID: 22292807 Review.
-
Blood-brain barrier interfaces and brain tumors.Arch Pharm Res. 2006 Apr;29(4):265-75. doi: 10.1007/BF02968569. Arch Pharm Res. 2006. PMID: 16681030 Review.
-
Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain.Neurochem Res. 2017 Sep;42(9):2519-2536. doi: 10.1007/s11064-017-2313-x. Epub 2017 Jun 20. Neurochem Res. 2017. PMID: 28634726 Review.
Cited by
-
The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology.Antioxidants (Basel). 2024 Oct 8;13(10):1208. doi: 10.3390/antiox13101208. Antioxidants (Basel). 2024. PMID: 39456461 Free PMC article. Review.
-
Astrocyte roles in traumatic brain injury.Exp Neurol. 2016 Jan;275 Pt 3(0 3):305-315. doi: 10.1016/j.expneurol.2015.03.020. Epub 2015 Mar 28. Exp Neurol. 2016. PMID: 25828533 Free PMC article. Review.
-
Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders.Neurosci Bull. 2023 Mar;39(3):503-518. doi: 10.1007/s12264-022-00977-9. Epub 2022 Nov 14. Neurosci Bull. 2023. PMID: 36374471 Free PMC article. Review.
-
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases.Front Integr Neurosci. 2016 Jul 20;10:26. doi: 10.3389/fnint.2016.00026. eCollection 2016. Front Integr Neurosci. 2016. PMID: 27489539 Free PMC article. Review.
-
Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells.Glia. 2015 Jul;63(7):1200-12. doi: 10.1002/glia.22811. Epub 2015 Mar 20. Glia. 2015. PMID: 25802219 Free PMC article.
References
-
- Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006;7:41–53. - PubMed
-
- Adams RH. Vascular patterning by Eph receptor tyrosine kinases and ephrins. Semin Cell Dev Biol. 2002;13:55–60. - PubMed
-
- Adner M, Jansen I, Edvinsson L. Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries. J Auton Nerv Syst. 1994;49(Suppl):S117–S121. - PubMed
-
- Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben-Ze'ev A, Bromberg JF, Lamberti C, Verma U, Gaynor RB, Byers SW, Pestell RG. IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell. 2003;14:585–599. - PMC - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources