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Review
. 2013 Dec;10(12):707-22.
doi: 10.1038/nrcardio.2013.158. Epub 2013 Oct 22.

Mechanical antithrombotic intervention by LAA occlusion in atrial fibrillation

Cheuk-Man Yu  1 , Ahmed A Khattab, Stefan C Bertog, Alex P W Lee, Joey S W Kwong, Horst Sievert, Bernhard Meier
Affiliations
Review

Mechanical antithrombotic intervention by LAA occlusion in atrial fibrillation

Cheuk-Man Yu et al. Nat Rev Cardiol. 2013 Dec.

Abstract

Stroke in patients with atrial fibrillation (AF) is often associated with substantial morbidity and mortality. Oral anticoagulation remains the first-line approach to stroke prevention in such individuals; however, for a considerable proportion of patients, traditional treatment using warfarin is limited by a number of factors, such as the inconvenience of frequent therapeutic monitoring and the risk of haemorrhage. The development of new oral anticoagulants with improved efficacy and safety profiles has provided viable options for oral anticoagulation therapy in patients with nonvalvular (nonrheumatic AF). Nonetheless, in patients who have an increased risk of major haemorrhage, a nonpharmacological approach to antithrombotic therapy remains an attractive alternative. The left atrial appendage (LAA) has been found to be the source of >90% of thrombi in patients with nonvalvular AF; thus, prevention of thrombus formation via transcatheter mechanical LAA occlusion is a novel therapeutic _target for stroke prevention in this patient population. In this Review, we present the rationale for LAA occlusion in patients with AF, the available occlusion devices and their clinical evidence to date. We also discuss the roles of various imaging techniques in device implantation and the management strategy for associated procedural complications.

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