Neurodevelopment in schizophrenia: the role of the wnt pathways

doi:10.2174/1570159X113119990037

. 2013 Sep;11(5):535-58.

doi: 10.2174/1570159X113119990037.

Neurodevelopment in schizophrenia: the role of the wnt pathways

Isabella Panaccione¹, Flavia Napoletano¹, Alberto Maria Forte¹, Giorgio D Kotzalidis¹, Antonio Del Casale¹, Chiara Rapinesi¹, Chiara Brugnoli¹, Daniele Serata¹, Federica Caccia¹, Ilaria Cuomo¹, Elisa Ambrosi¹, Alessio Simonetti¹, Valeria Savoja¹, Lavinia De Chiara¹, Emanuela Danese¹, Giovanni Manfredi¹, Delfina Janiri¹, Marta Motolese², Ferdinando Nicoletti³, Paolo Girardi⁴, Gabriele Sani⁵

Affiliations

¹ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy;
² NEUROMED, Pozzilli, Isernia, Italy;
³ NEUROMED, Pozzilli, Isernia, Italy; ; Department of Neuropharmacology, Sapienza University, School of Medicine and Pharmacy, Rome, Italy;
⁴ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; ; Centro Lucio Bini, Rome, Italy;
⁵ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; ; Centro Lucio Bini, Rome, Italy; ; IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Neuropsychiatry Laboratory, Rome, Italy.

PMID: 24403877
PMCID: PMC3763761
DOI: 10.2174/1570159X113119990037

Neurodevelopment in schizophrenia: the role of the wnt pathways

Isabella Panaccione et al. Curr Neuropharmacol. 2013 Sep.

. 2013 Sep;11(5):535-58.

doi: 10.2174/1570159X113119990037.

Authors

Affiliations

¹ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy;
² NEUROMED, Pozzilli, Isernia, Italy;
³ NEUROMED, Pozzilli, Isernia, Italy; ; Department of Neuropharmacology, Sapienza University, School of Medicine and Pharmacy, Rome, Italy;
⁴ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; ; Centro Lucio Bini, Rome, Italy;
⁵ NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy; ; Centro Lucio Bini, Rome, Italy; ; IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Neuropsychiatry Laboratory, Rome, Italy.

PMID: 24403877
PMCID: PMC3763761
DOI: 10.2174/1570159X113119990037

Abstract

Objectives: To review the role of Wnt pathways in the neurodevelopment of schizophrenia.

Methods: SYSTEMATIC PUBMED SEARCH, USING AS KEYWORDS ALL THE TERMS RELATED TO THE WNT PATHWAYS AND CROSSING THEM WITH EACH OF THE FOLLOWING AREAS: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.

Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to the pathophysiology of schizophrenia or to antipsychotic action remains to be established.

Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological _targets must await the collection of more data.

Keywords: Antipsychotic Drugs; Neurodevelopment; Schizophrenia; Wingless (Wnt) signalling..

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Figures

**Fig. (1)**
Simplified drawing of putative interactions between canonical Wnt and other pathways to illustrate their complex interplay. Dashed lines indicate inhibition, solid lines activation.

See this image and copyright information in PMC

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References

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[1] Huber G. Reine Defektsyndrome und Basisstadien endogener Psychosen. Fortschr. Neurol. Psychiatr. 1966;34:409–426.

[2] Huber G. Reine Defektsyndrome und Basisstadien endogener Psychosen. Fortschr. Neurol. Psychiatr. 1966;34:409–426.

[3] Feinberg I. Schizophrenia caused by a fault in programmed synaptic elimination during adolescence. J. Psychiatr. Res. 1982. 1983;17:319–334. - PubMed

[4] Feinberg I. Schizophrenia caused by a fault in programmed synaptic elimination during adolescence. J. Psychiatr. Res. 1982. 1983;17:319–334. - PubMed

[5] Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 1987;44:660–669. - PubMed

[6] Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 1987;44:660–669. - PubMed

[7] Murray RM, Lewis SW. Is schizophrenia a neurodevelopmental disorder. BMJ. 1987;295:681–682. - PMC - PubMed

[8] Murray RM, Lewis SW. Is schizophrenia a neurodevelopmental disorder. BMJ. 1987;295:681–682. - PMC - PubMed

[9] Crow TJ. Positive and negative schizophrenic symptoms and the role of dopamine. Br. J. Psychiatry. 1980;137:383–386. - PubMed

[10] Crow TJ. Positive and negative schizophrenic symptoms and the role of dopamine. Br. J. Psychiatry. 1980;137:383–386. - PubMed

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Neurodevelopment in schizophrenia: the role of the wnt pathways

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Neurodevelopment in schizophrenia: the role of the wnt pathways

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