Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr;57(4):660-71.
doi: 10.1007/s00125-014-3171-6. Epub 2014 Jan 30.

Molecular mechanisms of diabetic cardiomyopathy

Heiko Bugger  1 , E Dale Abel
Affiliations
Review

Molecular mechanisms of diabetic cardiomyopathy

Heiko Bugger et al. Diabetologia. 2014 Apr.

Abstract

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.

PubMed Disclaimer

Conflict of interest statement

Duality of interest

The authors declare that there is no duality of interest associated with this manuscript

Figures

Fig. 1
Fig. 1
Schematic depiction of the multiple potential mechanisms that have been implicated in the pathophysiology of diabetic cardiomyopathy. Although depicted as separate mechanisms, these pathways interact with each other in complex ways. Examples include: (1) increased FA oxidation and lipotoxicity may promote mitochondrial dysfunction; (2) mitochondrial dysfunction and ER stress may increase apoptosis; (3) oxidative stress, increased AGE signalling and inflammation may promote increased expression of pro-fibrotic genes or promote apoptosis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. American Diabetes Association. [accessed 25/12/2013];Diabetes statistics. 2011 Available from www.diabetes.org/diabetes-basics/diabetes-statistics/
    1. Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol. 1972;30:595–602. - PubMed
    1. de Simone G, Devereux RB, Chinali M, et al. Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study. J Hypertens. 2010;28:353–360. - PMC - PubMed
    1. Litwin SE. Diabetes and the heart: is there objective evidence of a human diabetic cardiomyopathy? Diabetes. 2013;62:3329–3330. - PMC - PubMed
    1. Devereux RB, Roman MJ, Paranicas M, et al. Impact of diabetes on cardiac structure and function: the strong heart study. Circulation. 2000;101:2271–2276. - PubMed

Publication types

MeSH terms

  NODES
Association 1
twitter 2