Agreement in identification of glaucomatous progression between the optic disc photography and Heidelberg retina tomography in young glaucomatous patients

doi:10.3980/j.issn.2222-3959.2014.03.16

. 2014 Jun 18;7(3):474-9.

doi: 10.3980/j.issn.2222-3959.2014.03.16. eCollection 2014.

Agreement in identification of glaucomatous progression between the optic disc photography and Heidelberg retina tomography in young glaucomatous patients

Paraskeva Hentova-Sencanic¹, Ivan Sencanic², Goran Trajković³, Marija Bozic¹, Nevena Bjelovic⁴

Affiliations

¹ Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia ; Clinic for Eye Diseases, Clinical Center of Serbia, Pasterova 2, Belgrade 11000, Serbia.
² Clinic for Eye Diseases, University Medical Centre Zvezdara, Dimitrija Tucovica 161, Belgrade 11000, Serbia.
³ Insitute of Statistics, Faculty of Medicine, University of Belgrade, Serbia, Dr Subotica 8, Belgrade 11000, Serbia.
⁴ Center for Vision Oftalmika, Strahinjica bana 78, Belgrade 11000, Serbia.

PMID: 24967194
PMCID: PMC4067662
DOI: 10.3980/j.issn.2222-3959.2014.03.16

Agreement in identification of glaucomatous progression between the optic disc photography and Heidelberg retina tomography in young glaucomatous patients

Paraskeva Hentova-Sencanic et al. Int J Ophthalmol. 2014.

. 2014 Jun 18;7(3):474-9.

doi: 10.3980/j.issn.2222-3959.2014.03.16. eCollection 2014.

Authors

Paraskeva Hentova-Sencanic¹, Ivan Sencanic², Goran Trajković³, Marija Bozic¹, Nevena Bjelovic⁴

Affiliations

¹ Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia ; Clinic for Eye Diseases, Clinical Center of Serbia, Pasterova 2, Belgrade 11000, Serbia.
² Clinic for Eye Diseases, University Medical Centre Zvezdara, Dimitrija Tucovica 161, Belgrade 11000, Serbia.
³ Insitute of Statistics, Faculty of Medicine, University of Belgrade, Serbia, Dr Subotica 8, Belgrade 11000, Serbia.
⁴ Center for Vision Oftalmika, Strahinjica bana 78, Belgrade 11000, Serbia.

PMID: 24967194
PMCID: PMC4067662
DOI: 10.3980/j.issn.2222-3959.2014.03.16

Abstract

Aim: To evaluate concordance between the clinical assessment of glaucomatous progression of the optic disc photography and progression identified by Heidelberg Retina Tomograph (HRT) in patients with suspected primary juvenile open angle glaucoma (JOAG).

Methods: Optic disc photographs and corresponding HRT II series were reviewed. Optic disc changes between first and final photographs were noted as well as progression identified by HRT topographic change analysis (TCA) and rim area regression line (RARL) Agreement between progression indentified by photography and HRT methods was assessed. Progression, determined from optic disc photographs by consensus assessment was used as the reference standard.

Results: A total of 31 patients (59 eyes) with suspected JOAG were studied. Agreement for progression/no progression between TCA and photography was obtained in 4 progressing eyes and 38 stable eyes (71.19%, k=0.11). Agreement for progression/no progression between RARL and photography was detected in 5 progressing eyes and in 34 stable eyes (66.10%, k=0.15). The number of HRT per patient was statistically higher in the progressing group (P=0.034).

Conclusion: Agreement for detection of longitudinal changes between photography and HRT analysis was poor. One way to improve the chance of discovery of the progression could be increasing the number of HRT examinations.

Keywords: Heidelberg Retina Tomography; juvenile glaucoma; optic disc.

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Figures

**Figure 1. An example of the optic disc photographs and Heidelberg Retina Tomograph**
A: First and final optic disc photograph. Shifting of the blood vessel (marked with an arrow) suggests enlargement of the cup; B: HRT reflectivity image shows nasal enlargement; C: Rim are regression line (RARL) analysis demonstrates significant negative slope of the regression line.

Figure 2. Heidelberg Retina Tomograph Topographic change analysis(TCA). TCA during the follow-up time does not demonstrate significant progression (less than 3 contiguous red super pixels are present).

**Figure 3. Venn diagram showing the number of eyes classified as progressing by 3 progressing strategies: photographs assessment, HRT topographic change analysis and HRT rim area regression line.**

See this image and copyright information in PMC

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References

1. Feiti ME, Krupin T, Tanna AP. Juvenile glaucoma. In: Roz FH, Fraunfelder FW, Fraunfelder FT, editors. Current Ocular therapy. Amsterdam, The Netherlands: Elsevier; 2008. pp. 500–502.
1. Weinreb RN, Zangwill LM, Jain S, Becerra LM, Dirkes K, Piltz-Seymour JR, Cioffi GA, Trick GL, Coleman AL, Brandt JD, Liebmann JM, Gordon MO, Kass MA. Predicting the onset of glaucoma: the confocal scanning laser ophthalmoscopy ancillary study to the Ocular Hypertension Treatment Study. Ophthalmology. 2010;117(9):1674–1683. - PMC - PubMed
1. Gardiner SK, Johnson CA, Demirel S. Factors predicting the rate of functional progression in early and suspected glaucoma. Invest Ophthalmol Vis Sci. 2012;53(7):3598–3604. - PMC - PubMed
1. Zangwill LM, Weinreb RN, Beiser JA, Berry CC, Cioffi GA, Coleman AL, Trick G, Liebmann JM, Brandt JD, Piltz-Seymour JR, Dirkes KA, Vega S, Kass MA, Gordon MO. Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2005;123(9):1188–1197. - PubMed
1. Chauhan BC, Hutchison DM, Artes PH, Caprioli J, Jonas JB, LeBlanc RP, Nicolela MT. Optic disc progression in glaucoma: comparison of confocal scanning laser tomography to optic disc photographs in a prospective study. Invest Ophthalmol Vis Sci. 2009;50(4):1682–1691. - PubMed

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[1] Feiti ME, Krupin T, Tanna AP. Juvenile glaucoma. In: Roz FH, Fraunfelder FW, Fraunfelder FT, editors. Current Ocular therapy. Amsterdam, The Netherlands: Elsevier; 2008. pp. 500–502.

[2] Feiti ME, Krupin T, Tanna AP. Juvenile glaucoma. In: Roz FH, Fraunfelder FW, Fraunfelder FT, editors. Current Ocular therapy. Amsterdam, The Netherlands: Elsevier; 2008. pp. 500–502.

[3] Weinreb RN, Zangwill LM, Jain S, Becerra LM, Dirkes K, Piltz-Seymour JR, Cioffi GA, Trick GL, Coleman AL, Brandt JD, Liebmann JM, Gordon MO, Kass MA. Predicting the onset of glaucoma: the confocal scanning laser ophthalmoscopy ancillary study to the Ocular Hypertension Treatment Study. Ophthalmology. 2010;117(9):1674–1683. - PMC - PubMed

[4] Weinreb RN, Zangwill LM, Jain S, Becerra LM, Dirkes K, Piltz-Seymour JR, Cioffi GA, Trick GL, Coleman AL, Brandt JD, Liebmann JM, Gordon MO, Kass MA. Predicting the onset of glaucoma: the confocal scanning laser ophthalmoscopy ancillary study to the Ocular Hypertension Treatment Study. Ophthalmology. 2010;117(9):1674–1683. - PMC - PubMed

[5] Gardiner SK, Johnson CA, Demirel S. Factors predicting the rate of functional progression in early and suspected glaucoma. Invest Ophthalmol Vis Sci. 2012;53(7):3598–3604. - PMC - PubMed

[6] Gardiner SK, Johnson CA, Demirel S. Factors predicting the rate of functional progression in early and suspected glaucoma. Invest Ophthalmol Vis Sci. 2012;53(7):3598–3604. - PMC - PubMed

[7] Zangwill LM, Weinreb RN, Beiser JA, Berry CC, Cioffi GA, Coleman AL, Trick G, Liebmann JM, Brandt JD, Piltz-Seymour JR, Dirkes KA, Vega S, Kass MA, Gordon MO. Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2005;123(9):1188–1197. - PubMed

[8] Zangwill LM, Weinreb RN, Beiser JA, Berry CC, Cioffi GA, Coleman AL, Trick G, Liebmann JM, Brandt JD, Piltz-Seymour JR, Dirkes KA, Vega S, Kass MA, Gordon MO. Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2005;123(9):1188–1197. - PubMed

[9] Chauhan BC, Hutchison DM, Artes PH, Caprioli J, Jonas JB, LeBlanc RP, Nicolela MT. Optic disc progression in glaucoma: comparison of confocal scanning laser tomography to optic disc photographs in a prospective study. Invest Ophthalmol Vis Sci. 2009;50(4):1682–1691. - PubMed

[10] Chauhan BC, Hutchison DM, Artes PH, Caprioli J, Jonas JB, LeBlanc RP, Nicolela MT. Optic disc progression in glaucoma: comparison of confocal scanning laser tomography to optic disc photographs in a prospective study. Invest Ophthalmol Vis Sci. 2009;50(4):1682–1691. - PubMed

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Agreement in identification of glaucomatous progression between the optic disc photography and Heidelberg retina tomography in young glaucomatous patients

Affiliations

Agreement in identification of glaucomatous progression between the optic disc photography and Heidelberg retina tomography in young glaucomatous patients

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Abstract

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