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. 2014 Jul;20(7):2358.
doi: 10.1007/s00894-014-2358-6. Epub 2014 Jul 3.

Structural and functional alterations of myoglobin by glucose-protein interactions

Yong You  1 , Fang Liu, Ke-Jie Du, Ge-Bo Wen, Ying-Wu Lin
Affiliations

Structural and functional alterations of myoglobin by glucose-protein interactions

Yong You et al. J Mol Model. 2014 Jul.

Abstract

The interaction of blood glucose with heme proteins plays a key role in inducing diabetes, a serious disease threatening human health. In this study, we investigated the non-covalent interaction between glucose and myoglobin (Mb), both theoretically and experimentally, using molecular dynamics (MD) simulation combined with spectroscopic studies. It revealed that glucoses can occupy the side pocket of Mb, and bind closely to one of the xenon cavities in Mb, by hydrogen bonding interactions with two propionate groups of heme as well as surrounding amino acids. These interactions alter the conformation of the heme active site slightly and lead to an enhanced peroxidase activity of Mb, as determined by kinetic studies. This study provides general information for glucose-heme proteins interactions, and also for blood glucose-protein interactions for patients with diabetes.

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References

    1. Chem Rev. 2006 May;106(5):1898-916 - PubMed
    1. J Mol Model. 2012 Apr;18(4):1591-6 - PubMed
    1. J Biol Chem. 1984 Nov 10;259(21):13027-36 - PubMed
    1. J Am Chem Soc. 2010 Jan 27;132(3):1010-7 - PubMed
    1. Methods Mol Biol. 2010;654:423-40 - PubMed

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