The roles of microphthalmia-associated transcription factor and pigmentation in melanoma
- PMID: 25111671
- PMCID: PMC4336945
- DOI: 10.1016/j.abb.2014.07.019
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma
Abstract
MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many _targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
Keywords: MITF; Melanocyte; Melanoma; Pigmentation.
Figures
![Figure 1](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9e/4336945/c0e19e0ce1e8/nihms-620704-f0001.gif)
![Figure 2](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9e/4336945/26b349691bae/nihms-620704-f0002.gif)
![Figure 3](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9e/4336945/e9644c9e9fa4/nihms-620704-f0003.gif)
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