PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas
- PMID: 25115512
- DOI: 10.3109/10428194.2014.953155
PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas
Abstract
The gene encoding the human BLIMP1, prdm1, is located on chromosome 6q21, a locus frequently deleted in lymphoid tumors. BLIMP1 is able to silence its _target genes in a context-dependent manner through different mechanisms. BLIMP1 is expressed in both B and T cells, in which it plays important functions. In B cells, BLIMP1 acts as the master regulator of plasma cell differentiation, repressed by BCL6 and repressing both BCL6 and PAX5. In T cells, BLIMP1 is a critical factor for most terminal effector cell differentiation in both CD4+ and CD8+ T cells. BLIMP1 is frequently inactivated in a variety of lymphomas, including diffuse large B cell lymphomas, Natural Killer cell lymphoma and anaplastic large T cell lymphoma. In this review, we will summarize the role of BLIMP1 in normal cells, focusing on lymphoid cells, and on its function as tumor suppressor gene in lymphomas.
Keywords: ALCL; BCL6; BLIMP1; DLBCL; NK; PAX5; PRDM1.
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