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. 1989 Mar;51(2):165-70.
doi: 10.1016/s0163-1047(89)90797-8.

Retention enhancement with post-training picrotoxin: lack of state dependency

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Retention enhancement with post-training picrotoxin: lack of state dependency

C Castellano et al. Behav Neural Biol. 1989 Mar.

Abstract

Immediate post-training intraperitoneal administration of the GABA-antagonist picrotoxin (0.5 or 1.0 mg/kg) significantly enhanced retention of CD1 mice tested 24 h after training in an inhibitory avoidance task. Administration of picrotoxin prior to the retention test did not affect the retention performance of mice given post-training injections of either saline or picrotoxin. These findings indicate that the memory-enhancing effects of post-training administration of picrotoxin are not state-dependent.

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