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Review
. 2015 Apr:33:88-94.
doi: 10.1016/j.ceb.2014.12.005. Epub 2015 Jan 10.

Epigenetic modulation of metabolic decisions

Affiliations
Review

Epigenetic modulation of metabolic decisions

Anita Öst et al. Curr Opin Cell Biol. 2015 Apr.

Abstract

In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.

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