Review
doi: 10.1016/j.ceb.2014.12.005.
Epub 2015 Jan 10.
Epigenetic modulation of metabolic decisions
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- PMID: 25588618
- DOI: 10.1016/j.ceb.2014.12.005
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Review
Epigenetic modulation of metabolic decisions
Curr Opin Cell Biol.
2015 Apr.
Abstract
In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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