Sirtuins in epigenetic regulation

doi:10.1021/cr500457h

Review

. 2015 Mar 25;115(6):2350-75.

doi: 10.1021/cr500457h. Epub 2015 Jan 28.

Sirtuins in epigenetic regulation

Hui Jing¹, Hening Lin¹

Affiliations

PMID: 25804908
PMCID: PMC4610301
DOI: 10.1021/cr500457h

Review

Sirtuins in epigenetic regulation

Hui Jing et al. Chem Rev. 2015.

. 2015 Mar 25;115(6):2350-75.

doi: 10.1021/cr500457h. Epub 2015 Jan 28.

Authors

Hui Jing¹, Hening Lin¹

Affiliation

¹ Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, United States.

PMID: 25804908
PMCID: PMC4610301
DOI: 10.1021/cr500457h

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interest.

Figures

**Figure 1**
Enzymatic function of sirtuins. (A) NAD-dependent protein lysine deacylation activity of different sirtuins. (B) Enzymatic reaction mechanism of sirtuins. (C) Structure of a ternary sirtuin-NAD-acetyl peptide complex (PDB ID 2H4F). NAD, acetyl lysine, and the key catalytic His residue are shown in stick representation. Bound zinc is shown as a gray sphere. Protein structure picture is generated using PyMol.

**Figure 2**
Models for the role of SIR2 in gene silencing in yeast. (A) SIR2 and SIR complex at the silent mating-type loci and telomeric heterochromatin. (B) SIR2 at silenced rDNA loci.

**Figure 3**
Model for SIRT1-mediated heterochromatin formation and transcriptional silencing.

See this image and copyright information in PMC

Cited by

Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites.
Zhang B, Mullmann J, Ludewig AH, Fernandez IR, Bales TR, Weiss RS, Schroeder FC. Zhang B, et al. Nat Chem Biol. 2024 Jul;20(7):812-822. doi: 10.1038/s41589-023-01511-2. Epub 2024 Jan 2. Nat Chem Biol. 2024. PMID: 38167917
Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy.
Tomasetti M, Gaetani S, Monaco F, Neuzil J, Santarelli L. Tomasetti M, et al. Front Oncol. 2019 Nov 29;9:1293. doi: 10.3389/fonc.2019.01293. eCollection 2019. Front Oncol. 2019. PMID: 31850200 Free PMC article. Review.
The Role of Epigenetics in Neuroinflammatory-Driven Diseases.
Giallongo S, Longhitano L, Denaro S, D'Aprile S, Torrisi F, La Spina E, Giallongo C, Mannino G, Lo Furno D, Zappalà A, Giuffrida R, Parenti R, Li Volti G, Tibullo D, Vicario N. Giallongo S, et al. Int J Mol Sci. 2022 Dec 2;23(23):15218. doi: 10.3390/ijms232315218. Int J Mol Sci. 2022. PMID: 36499544 Free PMC article. Review.
Characterization of Histone Deacetylase Mechanisms in Cancer Development.
Hai R, He L, Shu G, Yin G. Hai R, et al. Front Oncol. 2021 Jul 29;11:700947. doi: 10.3389/fonc.2021.700947. eCollection 2021. Front Oncol. 2021. PMID: 34395273 Free PMC article. Review.
The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms.
Dzidek A, Czerwińska-Ledwig O, Żychowska M, Pilch W, Piotrowska A. Dzidek A, et al. Int J Mol Sci. 2023 Jun 2;24(11):9655. doi: 10.3390/ijms24119655. Int J Mol Sci. 2023. PMID: 37298604 Free PMC article. Review.

See all "Cited by" articles

References

1. Rine J.; Herskowitz I. Genetics 1987, 116, 9–22. - PMC - PubMed
1. Aparicio O. M.; Billington B. L.; Gottschling D. E. Cell 1991, 66, 1279–1287. - PubMed
1. Smith J. S.; Boeke J. D. Genes Dev. 1997, 11, 241–254. - PubMed
1. Bryk M.; Banerjee M.; Murphy M.; Knudsen K. E.; Garfinkel D. J.; Curcio M. J. Genes Dev. 1997, 11, 255–269. - PubMed
1. Gotta M.; Strahl-Bolsinger S.; Renauld H.; Laroche T.; Kennedy B. K.; Grunstein M.; Gasser S. M. EMBO J. 1997, 16, 3243–3255. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

R01 GM086703/GM/NIGMS NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Molecular Biology Databases
- Saccharomyces Genome Database

[1] Rine J.; Herskowitz I. Genetics 1987, 116, 9–22. - PMC - PubMed

[2] Rine J.; Herskowitz I. Genetics 1987, 116, 9–22. - PMC - PubMed

[3] Aparicio O. M.; Billington B. L.; Gottschling D. E. Cell 1991, 66, 1279–1287. - PubMed

[4] Aparicio O. M.; Billington B. L.; Gottschling D. E. Cell 1991, 66, 1279–1287. - PubMed

[5] Smith J. S.; Boeke J. D. Genes Dev. 1997, 11, 241–254. - PubMed

[6] Smith J. S.; Boeke J. D. Genes Dev. 1997, 11, 241–254. - PubMed

[7] Bryk M.; Banerjee M.; Murphy M.; Knudsen K. E.; Garfinkel D. J.; Curcio M. J. Genes Dev. 1997, 11, 255–269. - PubMed

[8] Bryk M.; Banerjee M.; Murphy M.; Knudsen K. E.; Garfinkel D. J.; Curcio M. J. Genes Dev. 1997, 11, 255–269. - PubMed

[9] Gotta M.; Strahl-Bolsinger S.; Renauld H.; Laroche T.; Kennedy B. K.; Grunstein M.; Gasser S. M. EMBO J. 1997, 16, 3243–3255. - PMC - PubMed

[10] Gotta M.; Strahl-Bolsinger S.; Renauld H.; Laroche T.; Kennedy B. K.; Grunstein M.; Gasser S. M. EMBO J. 1997, 16, 3243–3255. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Sirtuins in epigenetic regulation

Affiliation

Sirtuins in epigenetic regulation

Authors

Affiliation

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases