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Review
. 2015 Mar 25;115(6):2350-75.
doi: 10.1021/cr500457h. Epub 2015 Jan 28.

Sirtuins in epigenetic regulation

Hui Jing  1 , Hening Lin  1
Affiliations
Review

Sirtuins in epigenetic regulation

Hui Jing et al. Chem Rev. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Enzymatic function of sirtuins. (A) NAD-dependent protein lysine deacylation activity of different sirtuins. (B) Enzymatic reaction mechanism of sirtuins. (C) Structure of a ternary sirtuin-NAD-acetyl peptide complex (PDB ID 2H4F). NAD, acetyl lysine, and the key catalytic His residue are shown in stick representation. Bound zinc is shown as a gray sphere. Protein structure picture is generated using PyMol.
Figure 2
Figure 2
Models for the role of SIR2 in gene silencing in yeast. (A) SIR2 and SIR complex at the silent mating-type loci and telomeric heterochromatin. (B) SIR2 at silenced rDNA loci.
Figure 3
Figure 3
Model for SIRT1-mediated heterochromatin formation and transcriptional silencing.
See this image and copyright information in PMC

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