Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

doi:10.1016/j.cyto.2015.03.001

Review

. 2015 Aug;74(2):171-4.

doi: 10.1016/j.cyto.2015.03.001. Epub 2015 Mar 25.

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Darren J Perkins¹, Stefanie N Vogel²

Affiliations

¹ Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States.
² Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States. Electronic address: svogel@som.umaryland.edu.

PMID: 25819430
PMCID: PMC4475459
DOI: 10.1016/j.cyto.2015.03.001

Review

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Darren J Perkins et al. Cytokine. 2015 Aug.

. 2015 Aug;74(2):171-4.

doi: 10.1016/j.cyto.2015.03.001. Epub 2015 Mar 25.

Authors

Darren J Perkins¹, Stefanie N Vogel²

Affiliations

¹ Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States.
² Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States. Electronic address: svogel@som.umaryland.edu.

PMID: 25819430
PMCID: PMC4475459
DOI: 10.1016/j.cyto.2015.03.001

Abstract

The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation.

Keywords: IFN-β; Interferon; LPS; TLR; TRAF3.

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References

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1. Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071–82. - PubMed
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1. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410:1099–103. - PubMed
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[1] Jin MS, Lee JO. Structures of the toll-like receptor family and its ligand complexes. Immunity. 2008;29:182–91. - PubMed

[2] Jin MS, Lee JO. Structures of the toll-like receptor family and its ligand complexes. Immunity. 2008;29:182–91. - PubMed

[3] Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071–82. - PubMed

[4] Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071–82. - PubMed

[5] Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732–8. - PubMed

[6] Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732–8. - PubMed

[7] Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410:1099–103. - PubMed

[8] Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410:1099–103. - PubMed

[9] Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303:1529–31. - PubMed

[10] Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303:1529–31. - PubMed

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Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Affiliations

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

Authors

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Abstract

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