Deubiquitinases in cancer

doi:10.18632/onco_target.3671

Review

. 2015 May 30;6(15):12872-89.

doi: 10.18632/onco_target.3671.

Deubiquitinases in cancer

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
³ Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.

PMID: 25972356
PMCID: PMC4536986
DOI: 10.18632/onco_target.3671

Review

Deubiquitinases in cancer

Rongbin Wei et al. Onco_target. 2015.

. 2015 May 30;6(15):12872-89.

doi: 10.18632/onco_target.3671.

Authors

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
³ Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.

PMID: 25972356
PMCID: PMC4536986
DOI: 10.18632/onco_target.3671

Abstract

Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug _targets.

Keywords: cancer; deubiquitinases; inhibitor; ubiquitylation.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflict of interest.

Cited by

Identification of new leads against ubiquitin specific protease-7 (USP7): a step towards the potential treatment of cancers.
Javaid S, Zadi S, Awais M, Wahab AT, Zafar H, Maslennikov I, Choudhary MI. Javaid S, et al. RSC Adv. 2024 Oct 21;14(45):33080-33093. doi: 10.1039/d4ra06813k. eCollection 2024 Oct 17. RSC Adv. 2024. PMID: 39435002 Free PMC article.
The Ubiquitin Proteasome System in Ischemic and Dilated Cardiomyopathy.
Spänig S, Kellermann K, Dieterlen MT, Noack T, Lehmann S, Borger MA, Garbade J, Barac YD, Emrich F. Spänig S, et al. Int J Mol Sci. 2019 Dec 17;20(24):6354. doi: 10.3390/ijms20246354. Int J Mol Sci. 2019. PMID: 31861129 Free PMC article.
Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition.
Patel K, Ahmed ZS, Huang X, Yang Q, Ekinci E, Neslund-Dudas CM, Mitra B, Elnady FA, Ahn YH, Yang H, Liu J, Dou QP. Patel K, et al. Future Med Chem. 2018 Sep 1;10(17):2087-2108. doi: 10.4155/fmc-2018-0091. Epub 2018 Aug 1. Future Med Chem. 2018. PMID: 30066579 Free PMC article. Review.
DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery.
Kapadia BB, Gartenhaus RB. Kapadia BB, et al. Mol Cancer Ther. 2019 Sep;18(9):1475-1483. doi: 10.1158/1535-7163.MCT-19-0307. Mol Cancer Ther. 2019. PMID: 31481479 Free PMC article. Review.
The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review.
Kumar P, Kumar P, Mandal D, Velayutham R. Kumar P, et al. Front Cell Infect Microbiol. 2022 Sep 27;12:985178. doi: 10.3389/fcimb.2022.985178. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36237424 Free PMC article. Review.

See all "Cited by" articles

References

1. Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed
1. Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed
1. Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed
1. Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed
1. Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

[1] Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed

[2] Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed

[3] Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed

[4] Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed

[5] Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed

[6] Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed

[7] Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed

[8] Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed

[9] Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

[10] Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Deubiquitinases in cancer

Affiliations

Deubiquitinases in cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources