Deubiquitinases in cancer

doi:10.18632/onco_target.3671

Review

. 2015 May 30;6(15):12872-89.

doi: 10.18632/onco_target.3671.

Deubiquitinases in cancer

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
³ Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.

PMID: 25972356
PMCID: PMC4536986
DOI: 10.18632/onco_target.3671

Review

Deubiquitinases in cancer

Rongbin Wei et al. Onco_target. 2015.

. 2015 May 30;6(15):12872-89.

doi: 10.18632/onco_target.3671.

Authors

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
³ Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.

PMID: 25972356
PMCID: PMC4536986
DOI: 10.18632/onco_target.3671

Abstract

Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug _targets.

Keywords: cancer; deubiquitinases; inhibitor; ubiquitylation.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflict of interest.

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References

1. Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed
1. Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed
1. Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed
1. Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed
1. Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

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[1] Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed

[2] Fraile J, et al. Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 2011;31:2373–2388. - PubMed

[3] Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed

[4] Pickart CM. Mechanisms underlying ubiquitination. Annual review of biochemistry. 2001;70:503–533. - PubMed

[5] Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed

[6] Kerscher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006;22:159–180. - PubMed

[7] Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed

[8] Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. EMBO reports. 2008;9:536–542. - PMC - PubMed

[9] Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

[10] Komander D, Clague MJ, Urbé S. Breaking the chains: structure and function of the deubiquitinases. Nature reviews Molecular cell biology. 2009;10:550–563. - PubMed

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Deubiquitinases in cancer

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Deubiquitinases in cancer

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