BMP10 inhibited the growth and migration of gastric cancer cells

doi:10.1007/s13277-015-4116-5

. 2016 Mar;37(3):3025-31.

doi: 10.1007/s13277-015-4116-5. Epub 2015 Sep 29.

BMP10 inhibited the growth and migration of gastric cancer cells

Haiming Lei¹, Jian Wang², Peihua Lu³, Xinghua Si¹, Koulan Han¹, Tingyan Ruan³, Junjie Lu⁴

Affiliations

¹ Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China.
² Department of Gastrointestinal Surgery, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, No. 62, Huai-hai South Road, Huai'an, 223002, Jiangsu, China.
³ Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
⁴ Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, No. 75, Tongzhenguan Road, Yixing, 214200, Jiangsu, China. lujunjie0723@sina.com.

PMID: 26419594
DOI: 10.1007/s13277-015-4116-5

BMP10 inhibited the growth and migration of gastric cancer cells

Haiming Lei et al. Tumour Biol. 2016 Mar.

. 2016 Mar;37(3):3025-31.

doi: 10.1007/s13277-015-4116-5. Epub 2015 Sep 29.

Authors

Haiming Lei¹, Jian Wang², Peihua Lu³, Xinghua Si¹, Koulan Han¹, Tingyan Ruan³, Junjie Lu⁴

Affiliations

¹ Department of Clinical Medicine, Yancheng Institute of Health Sciences, No. 263, South Jiefang Road, Yancheng, 224005, Jiangsu, China.
² Department of Gastrointestinal Surgery, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, No. 62, Huai-hai South Road, Huai'an, 223002, Jiangsu, China.
³ Department of Medical Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
⁴ Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, No. 75, Tongzhenguan Road, Yixing, 214200, Jiangsu, China. lujunjie0723@sina.com.

PMID: 26419594
DOI: 10.1007/s13277-015-4116-5

Abstract

Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types. However, its roles in gastric cancer (GC) remain unknown. In this study, the expression of BMP10 was found to be down-regulated in GC samples. Forced expression of BMP10 in GC cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. BMP10 was shown to negatively regulated beta-catenin/TCF signaling by up-regulating Axin protein level. Taken together, the present study revealed the suppressive function of BMP10 in gastric cancer.

Keywords: Axin; BMP10; Beta-catenin/TCF signaling; Cell growth and migration.

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[1] Blood. 2007 Mar 1;109(5):1953-61 - PubMed

[2] Blood. 2007 Mar 1;109(5):1953-61 - PubMed

[3] Biochem Biophys Res Commun. 2010 Jan 22;391(4):1653-7 - PubMed

[4] Biochem Biophys Res Commun. 2010 Jan 22;391(4):1653-7 - PubMed

[5] Am J Pathol. 2002 May;160(5):1619-28 - PubMed

[6] Am J Pathol. 2002 May;160(5):1619-28 - PubMed

[7] Cell Cycle. 2012 Dec 1;11(23 ):4344-51 - PubMed

[8] Cell Cycle. 2012 Dec 1;11(23 ):4344-51 - PubMed

[9] J Biol Chem. 2006 Jun 23;281(25):17156-63 - PubMed

[10] J Biol Chem. 2006 Jun 23;281(25):17156-63 - PubMed

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BMP10 inhibited the growth and migration of gastric cancer cells

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BMP10 inhibited the growth and migration of gastric cancer cells

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