Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance
- PMID: 26424400
- DOI: 10.2174/1389450116666151001105230
Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance
Abstract
Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In particular, great interest has been given to polyphenols and especially to a specific subset of molecules, i.e. anthocyanins. Several lines of evidence suggest that anthocyanins have positive effects on human health by inducing a number of biological activities. This review will give an overview on the influence of dietary anthocyanins on preventing and managing type 2 diabetes. In particular, in vitro and in vivo studies will be presented. The article also reviews the potential clinical impact of the antidiabetic activity of anthocyanins and outlines the major challenges of using anthocyanins for diabetes treatment.
Keywords: Anthocyanins; anthocyanidins; antioxidant activity; cyanidin; diabetes; enzymatic mechanisms; non-enzymatic mechanisms.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Similar articles
-
Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits.J Agric Food Chem. 2005 Jan 12;53(1):28-31. doi: 10.1021/jf049018+. J Agric Food Chem. 2005. PMID: 15631504
-
Fruit, vegetables, and mushrooms for the preparation of extracts with α-amylase and α-glucosidase inhibition properties: A review.Food Chem. 2021 Feb 15;338:128119. doi: 10.1016/j.foodchem.2020.128119. Epub 2020 Sep 17. Food Chem. 2021. PMID: 33091976 Review.
-
The update of anthocyanins on obesity and type 2 diabetes: experimental evidence and clinical perspectives.Rev Endocr Metab Disord. 2015 Mar;16(1):1-13. doi: 10.1007/s11154-014-9302-z. Rev Endocr Metab Disord. 2015. PMID: 25557610 Review.
-
The inhibitory effects of berry polyphenols on digestive enzymes.Biofactors. 2005;23(4):189-95. doi: 10.1002/biof.5520230403. Biofactors. 2005. PMID: 16498205 Review.
-
Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications.Curr Med Chem. 2018;25(39):5347-5371. doi: 10.2174/0929867325666171206101945. Curr Med Chem. 2018. PMID: 29210634 Review.
Cited by
-
The Role of Cyanidin-3-O-glucoside in Modulating Oxaliplatin Resistance by Reversing Mesenchymal Phenotype in Colorectal Cancer.Nutrients. 2023 Nov 7;15(22):4705. doi: 10.3390/nu15224705. Nutrients. 2023. PMID: 38004099 Free PMC article.
-
Radish (Raphanus sativus) and Diabetes.Nutrients. 2017 Sep 14;9(9):1014. doi: 10.3390/nu9091014. Nutrients. 2017. PMID: 28906451 Free PMC article. Review.
-
Potential effect of tropical fruits Phyllanthus emblica L. for the prevention and management of type 2 diabetic complications: a systematic review of recent advances.Eur J Nutr. 2021 Oct;60(7):3525-3542. doi: 10.1007/s00394-020-02471-2. Epub 2021 Jan 13. Eur J Nutr. 2021. PMID: 33439332 Review.
-
Statistics on the bioactive anthocyanin/proanthocyanin products in China online sales.Food Sci Nutr. 2021 Jul 29;9(10):5428-5434. doi: 10.1002/fsn3.2500. eCollection 2021 Oct. Food Sci Nutr. 2021. PMID: 34646513 Free PMC article.
-
Tropaeolum majus R2R3 MYB Transcription Factor TmPAP2 Functions as a Positive Regulator of Anthocyanin Biosynthesis.Int J Mol Sci. 2022 Oct 17;23(20):12395. doi: 10.3390/ijms232012395. Int J Mol Sci. 2022. PMID: 36293253 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
