Autophagy and AML--food for thought

doi:10.1038/cdd.2015.136

. 2016 Jan;23(1):5-6.

doi: 10.1038/cdd.2015.136. Epub 2015 Oct 30.

Autophagy and AML--food for thought

N Lalaoui¹, R Johnstone², P G Ekert³

Affiliations

¹ Cell Signaling and Cell Death Division, Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, VIC, Australia.
² Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
³ Children's Cancer Centre Laboratory, Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, Australia.

PMID: 26517530
PMCID: PMC4815968
DOI: 10.1038/cdd.2015.136

Autophagy and AML--food for thought

N Lalaoui et al. Cell Death Differ. 2016 Jan.

. 2016 Jan;23(1):5-6.

doi: 10.1038/cdd.2015.136. Epub 2015 Oct 30.

Authors

N Lalaoui¹, R Johnstone², P G Ekert³

Affiliations

¹ Cell Signaling and Cell Death Division, Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, VIC, Australia.
² Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
³ Children's Cancer Centre Laboratory, Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, Australia.

PMID: 26517530
PMCID: PMC4815968
DOI: 10.1038/cdd.2015.136

No abstract available

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Figures

**Figure 1**
In mouse models of MLL-driven leukemia (left panel), Watson *et al.* show heterozygous deletion of *Atg5* gene increases leukemogeneisis, whereas loss of both alleles is deleterious for leukemic cells. In human hematopoiesis (right panel), the more differentiated myeloid hematopoietic cells represses autophagic flux. However, in human leukemic cells, there is copy-number loss of chromosomal regions that encode a number of autophagy genes, and this occurs more frequently than might be expected by chance alone. That raises the possibility that that decreased autophagy flux, as a result of haploinsufficiency of autophagy genes, might contribute to the development of acute myeloid leukemia

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References

1. Watson AS et al. Cell Death Discovery 2015; 1: 15008. - PMC - PubMed
1. Mortensen M et al. J Exp Med. 2011; 208: 455–467. - PMC - PubMed
1. Forbes SA et al. Nucleic Acids Res 2015; 43(Database issue): D805–D811. - PMC - PubMed
1. Qu X et al. J Clin Invest 2003; 112: 1809–1820. - PMC - PubMed
1. Wang L et al. Cancer Biol Ther 2015; 16: 383–391. - PMC - PubMed

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[1] Watson AS et al. Cell Death Discovery 2015; 1: 15008. - PMC - PubMed

[2] Watson AS et al. Cell Death Discovery 2015; 1: 15008. - PMC - PubMed

[3] Mortensen M et al. J Exp Med. 2011; 208: 455–467. - PMC - PubMed

[4] Mortensen M et al. J Exp Med. 2011; 208: 455–467. - PMC - PubMed

[5] Forbes SA et al. Nucleic Acids Res 2015; 43(Database issue): D805–D811. - PMC - PubMed

[6] Forbes SA et al. Nucleic Acids Res 2015; 43(Database issue): D805–D811. - PMC - PubMed

[7] Qu X et al. J Clin Invest 2003; 112: 1809–1820. - PMC - PubMed

[8] Qu X et al. J Clin Invest 2003; 112: 1809–1820. - PMC - PubMed

[9] Wang L et al. Cancer Biol Ther 2015; 16: 383–391. - PMC - PubMed

[10] Wang L et al. Cancer Biol Ther 2015; 16: 383–391. - PMC - PubMed

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Autophagy and AML--food for thought

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Autophagy and AML--food for thought

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