Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

doi:10.1186/s13020-016-0074-0

. 2016 Jan 28:11:2.

doi: 10.1186/s13020-016-0074-0. eCollection 2016.

Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

Mengjie Wang¹, Ling Tao², Hongxi Xu¹

Affiliations

¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China.
² School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China ; Xinxiang Medical University, Jinsui Road 601, Xinxiang, Henan 453003 China.

PMID: 26834824
PMCID: PMC4731985
DOI: 10.1186/s13020-016-0074-0

Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

Mengjie Wang et al. Chin Med. 2016.

. 2016 Jan 28:11:2.

doi: 10.1186/s13020-016-0074-0. eCollection 2016.

Authors

Mengjie Wang¹, Ling Tao², Hongxi Xu¹

Affiliations

¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China.
² School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China ; Xinxiang Medical University, Jinsui Road 601, Xinxiang, Henan 453003 China.

PMID: 26834824
PMCID: PMC4731985
DOI: 10.1186/s13020-016-0074-0

Abstract

Enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease (HFMD), which sometimes leads to severe neurological disease and death in the Asia-Pacific region. In Chinese medicine, HFMD is caused mainly by an accumulation of damp-heat and toxicity in the body. No effective drugs are currently available for the treatment and prevention of EV71 infection. This review summarizes the potential Chinese herbal extracts and isolated compounds with antiviral activity against EV71 and their clinical applications, especially those categorized as heat-clearing and detoxifying.

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Figures

**Fig. 1**
Mechanisms of anti-EV71 components. Mechanisms of anti-EV71 activities associated with the shown CM-derived extracts and molecules were classified into six categories

**Fig. 2**
Schematic diagram of the strategies used to assess anti-EV71 activities of Chinese herbal medicines. Shown are different methods that are used to screen for anti-EV71 activity in fractions and compounds from Chinese herbal medicines. The anti-EV71 mechanisms _target different points in the EV71 life cycle

See this image and copyright information in PMC

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References

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1. Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, Hsueh C, et al. Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet. 1999;354(9191):1682–1686. doi: 10.1016/S0140-6736(99)04434-7. - DOI - PubMed
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1. AbuBakar S, Sam IC, Yusof J, Lim MK, Misbah S, MatRahim N, et al. Enterovirus 71 outbreak, Brunei. Emerg Infect Dis. 2009;15(1):79–82. doi: 10.3201/eid1501.080264. - DOI - PMC - PubMed
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[1] Brown BA, Pallansch MA. Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus. Virus Res. 1995;39(2–3):195–205. doi: 10.1016/0168-1702(95)00087-9. - DOI - PubMed

[2] Brown BA, Pallansch MA. Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus. Virus Res. 1995;39(2–3):195–205. doi: 10.1016/0168-1702(95)00087-9. - DOI - PubMed

[3] Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, Hsueh C, et al. Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet. 1999;354(9191):1682–1686. doi: 10.1016/S0140-6736(99)04434-7. - DOI - PubMed

[4] Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, Hsueh C, et al. Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet. 1999;354(9191):1682–1686. doi: 10.1016/S0140-6736(99)04434-7. - DOI - PubMed

[5] McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev. 2002;26(1):91–107. doi: 10.1111/j.1574-6976.2002.tb00601.x. - DOI - PubMed

[6] McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev. 2002;26(1):91–107. doi: 10.1111/j.1574-6976.2002.tb00601.x. - DOI - PubMed

[7] AbuBakar S, Sam IC, Yusof J, Lim MK, Misbah S, MatRahim N, et al. Enterovirus 71 outbreak, Brunei. Emerg Infect Dis. 2009;15(1):79–82. doi: 10.3201/eid1501.080264. - DOI - PMC - PubMed

[8] AbuBakar S, Sam IC, Yusof J, Lim MK, Misbah S, MatRahim N, et al. Enterovirus 71 outbreak, Brunei. Emerg Infect Dis. 2009;15(1):79–82. doi: 10.3201/eid1501.080264. - DOI - PMC - PubMed

[9] Chumakov M, Voroshilova M, Shindarov L, Lavrova I, Gracheva L, Koroleva G, et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol. 1979;60(3–4):329–340. doi: 10.1007/BF01317504. - DOI - PubMed

[10] Chumakov M, Voroshilova M, Shindarov L, Lavrova I, Gracheva L, Koroleva G, et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol. 1979;60(3–4):329–340. doi: 10.1007/BF01317504. - DOI - PubMed

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Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

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Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

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