Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer's Disease Model Mouse
- PMID: 27060955
- DOI: 10.3233/JAD-151126
Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer's Disease Model Mouse
Abstract
Although chronic cerebral hypoperfusion (CCH) may affect Alzheimer's disease (AD) pathogenesis, the mechanism remains elusive. In the present study, we investigated the role of CCH on an AD mouse model in neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of galantamine. Alzheimer's disease transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive cerebral hypoperfusion. CCH exacerbated neuronal loss and decrease of α7 subunit of nicotinic acetylcholine receptors (α7-nAChRs) expression in hippocampus and thalamus at 12 months. Meanwhile, CCH greatly induced advanced glycation end products expression, and blood-brain barrier leakage through observing IgG and MMP9 expressions. Furthermore, a significant number of dramatic enlarged cerebral vessels with remodeling, BDNF/TrkB decreased in neurovascular trophic coupling. The present study demonstrated that CCH strongly enhanced primary AD pathology including neurodegeneration, neurovascular unit disruption, cerebrovascular remodeling and neurovascular trophic coupling damage in AD mice, and that galantamine treatment greatly ameliorated such neuropathologic abnormalities.
Keywords: APP23 mice; Alzheimer’s disease; cerebrovascular remodeling; chronic cerebral hypoperfusion; galantamine; neurovascular trophic coupling; neurovascular unit.
Similar articles
-
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310. doi: 10.1016/j.jstrokecerebrovasdis.2019.104310. Epub 2019 Aug 3. J Stroke Cerebrovasc Dis. 2019. PMID: 31383622
-
Chronic Cerebral Hypoperfusion Accelerates Alzheimer's Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model.J Alzheimers Dis. 2016 Jun 13;53(3):893-905. doi: 10.3233/JAD-160345. J Alzheimers Dis. 2016. PMID: 27314529
-
Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.029. Epub 2019 Apr 24. J Stroke Cerebrovasc Dis. 2019. PMID: 31029568
-
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease.Biochim Biophys Acta. 2016 May;1862(5):887-900. doi: 10.1016/j.bbadis.2015.12.016. Epub 2015 Dec 17. Biochim Biophys Acta. 2016. PMID: 26705676 Free PMC article. Review.
-
The role of neurovascular unit damage in the occurrence and development of Alzheimer's disease.Rev Neurosci. 2019 Jul 26;30(5):477-484. doi: 10.1515/revneuro-2018-0056. Rev Neurosci. 2019. PMID: 30530893 Review.
Cited by
-
Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice.Alzheimers Res Ther. 2019 May 10;11(1):42. doi: 10.1186/s13195-019-0498-8. Alzheimers Res Ther. 2019. PMID: 31077261 Free PMC article.
-
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.Ageing Res Rev. 2017 Mar;34:30-38. doi: 10.1016/j.arr.2016.09.011. Epub 2016 Oct 1. Ageing Res Rev. 2017. PMID: 27702698 Free PMC article. Review.
-
A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.J Alzheimers Dis. 2020;73(1):217-227. doi: 10.3233/JAD-191016. J Alzheimers Dis. 2020. PMID: 31771070 Free PMC article.
-
Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion.Neural Plast. 2019 Feb 24;2019:2158285. doi: 10.1155/2019/2158285. eCollection 2019. Neural Plast. 2019. PMID: 30923551 Free PMC article.
-
Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases.Neurochem Res. 2017 Dec;42(12):3446-3455. doi: 10.1007/s11064-017-2391-9. Epub 2017 Aug 24. Neurochem Res. 2017. PMID: 28836062
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
