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. 2016 Jun;24(6):1313-9.
doi: 10.1002/oby.21490. Epub 2016 Apr 18.

The effects of pre-pregnancy BMI and maternal factors on the timing of adiposity rebound in offspring

Jeannette Linares  1 , Camila Corvalán  2 , Bárbara Galleguillos  2 , Juliana Kain  2 , Laura González  2 , Ricardo Uauy  2 , María Luisa Garmendia  2 , Verónica Mericq  1
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Free article

The effects of pre-pregnancy BMI and maternal factors on the timing of adiposity rebound in offspring

Jeannette Linares et al. Obesity (Silver Spring). 2016 Jun.
Free article

Abstract

Objective: To assess the effect of pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and other maternal factors on the timing of adiposity rebound (AR).

Methods: In this study, 594 mothers (mothers who do not have diabetes and not underweight) from the longitudinal Growth and Obesity Chilean Cohort Study self-reported their weights at the beginning and end of their pregnancies, and their heights were measured. Pre-pregnancy BMI was categorized as normal weight, overweight, or obesity, and GWG was assessed according to Institute of Medicine guidelines. For children, weight and height measurements from 0 to 3 years were retrieved from records, and they were measured from age 4 to 7 years. BMI curves from 0 to 7 years were used to estimate the age at AR, which was categorized as early (<5 years), intermediate (5-7 years), or late (>7 years). The associations between pre-pregnancy BMI and GWG and early AR were tested using logistic regression models.

Results: In total, 33% of the mothers had excess pre-pregnancy weight, 31.2% exceeded Institute of Medicine recommendations, and 45% of children had early AR. The pre-pregnancy BMI and parity were associated with earlier AR (OR = 1.07, 95% CI = 1.02-1.11; OR = 0.86; 95% CI = 0.74-0.99, respectively), but GWG was unrelated.

Conclusions: These results suggest that preventive strategies for promoting normal pre-pregnancy BMI, especially in women's first pregnancies, could delay the timing of AR, with protective metabolic effects on offspring.

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