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Review
. 2013 Mar;29(2):142-50.

The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks

Pai-Feng Hsu  1 , Shao-Yuan Chuang  2 , Wen-Chung Yu  3 , Hsin-Bang Leu  4 , Wan-Leong Chan  4 , Chen-Huan Chen  5
Affiliations
Review

The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks

Pai-Feng Hsu et al. Acta Cardiol Sin. 2013 Mar.

Abstract

Hyperuricemia, and its clinical manifestation gout, is a metabolic disease process that has been recognized since the dawn of medical inquiry. Uric acid was hypothesized to be a mediator of cardiovascular disease for period of time. Epidemiological correlations of hyperuricemia with hypertension and cardiovascular events were evident for two centuries' studies. With recent animal studies shedding light on the causal mechanisms of hypertension, and clinical trials suggesting that urate-lowering therapy can lower blood pressure, there appears to be growing evidence of a connection between hyperuricemia and cardiovascular disease. To help bring this recent uric acid research into context, we have undertaken this narrative review of hyperuricemia, hypertension, its hemodynamics and its outcomes, and the risk for cardiovascular diseases.

Key words: Cardiovascular risk; Hemodynamics; Uric acid.

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Figures

Figure 1
Figure 1
Augmentation index (AIx) and the augmented pressure illustration.
Figure 2
Figure 2
The forward (Pf) and backward wave (Pb) decomposed from carotid wave form by triangulation method.
See this image and copyright information in PMC

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References

    1. Chang HY, Pan WH, Yeh WT, Tsai KS. Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993-96) J Rheumatol. 2001;28:1640–1646. - PubMed
    1. Chuang SY, Lee SC, Hsieh YT, Pan WH. Trends in hyperuricemia and gout prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008. Asia Pac J Clin Nutr. 2011;20:301–308. - PubMed
    1. Conen D, Wietlisbach V, Bovet P, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health. 2004;4:9. - PMC - PubMed
    1. Lee MS, Wahlqvist ML, Yu HL, Pan WH. Hyperuricemia and metabolic syndrome in Taiwanese children. Asia Pac J Clin Nutr. 2007;16:594–600. - PubMed
    1. Emmerson BT. The management of gout. N Engl J Med. 1996;15;334:445–451. - PubMed

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