Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

doi:10.1007/s12264-016-0038-5

Review

. 2016 Oct;32(5):463-8.

doi: 10.1007/s12264-016-0038-5. Epub 2016 Jun 1.

Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

Jiejie Li^{1

2

3

4}, Yongjun Wang^{5

6

7

8}

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
² China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
³ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.
⁴ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.
⁵ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁶ China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁷ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁸ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China. yongjunwang111@aliyun.com.

PMID: 27250628
PMCID: PMC5563758
DOI: 10.1007/s12264-016-0038-5

Review

Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

Jiejie Li et al. Neurosci Bull. 2016 Oct.

. 2016 Oct;32(5):463-8.

doi: 10.1007/s12264-016-0038-5. Epub 2016 Jun 1.

Authors

Jiejie Li^{1

2

3

4}, Yongjun Wang^{5

6

7

8}

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
² China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
³ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.
⁴ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.
⁵ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁶ China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁷ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China. yongjunwang111@aliyun.com.
⁸ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China. yongjunwang111@aliyun.com.

PMID: 27250628
PMCID: PMC5563758
DOI: 10.1007/s12264-016-0038-5

Abstract

Minor stroke and transient ischemic attack (TIA) are common disorders with a high rate of subsequent disabling stroke, so the early recognition and management of minor stroke and TIA is of great importance. At the moment, the diagnosis of these disorders is based on neurologic deficits in a stroke-clinician's examination of the patient, supplemented by the results of acute brain imaging. However, high variability in TIA diagnosis has been reported between physicians, even trained vascular neurologists, and image-based diagnostic confirmation is not always readily available. Some patients still have ischemic events despite sustained standard secondary preventive therapy. Blood biomarkers are promising to aid in the diagnosis, risk stratification, and individual treatment of minor stroke and TIA. Some studies are being conducted in this field. This mini-review aims to highlight potential biomarkers for diagnosis and those helpful in predicting the risk of future stroke and the selection of treatment.

Keywords: Biomarker; Diagnosis; Gene; Minor stroke; Prognosis; Protein; TIA.

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References

1. Zhao D, Liu J, Wang W, Zeng Z, Cheng J, Liu J, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke. 2008;39:1668–1674. doi: 10.1161/STROKEAHA.107.502807. - DOI - PubMed
1. Wang YL, Wu D, Liao X, Zhang W, Zhao X, Wang YJ. Burden of stroke in China. Int J Stroke. 2007;2:211–213. doi: 10.1111/j.1747-4949.2007.00142.x. - DOI - PubMed
1. Wang Y, Zhao X, Jiang Y, Li H, Wang L, Johnston SC, et al. Prevalence, knowledge, and treatment of transient ischemic attacks in China. Neurology. 2015;84:2354–2361. doi: 10.1212/WNL.0000000000001665. - DOI - PMC - PubMed
1. Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370:1432–1442. doi: 10.1016/S0140-6736(07)61448-2. - DOI - PubMed
1. Castle J, Mlynash M, Lee K, Caulfield AF, Wolford C, Kemp S, et al. Agreement regarding diagnosis of transient ischemic attack fairly low among stroke-trained neurologists. Stroke. 2010;41:1367–1370. doi: 10.1161/STROKEAHA.109.577650. - DOI - PubMed

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[1] Zhao D, Liu J, Wang W, Zeng Z, Cheng J, Liu J, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke. 2008;39:1668–1674. doi: 10.1161/STROKEAHA.107.502807. - DOI - PubMed

[2] Zhao D, Liu J, Wang W, Zeng Z, Cheng J, Liu J, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke. 2008;39:1668–1674. doi: 10.1161/STROKEAHA.107.502807. - DOI - PubMed

[3] Wang YL, Wu D, Liao X, Zhang W, Zhao X, Wang YJ. Burden of stroke in China. Int J Stroke. 2007;2:211–213. doi: 10.1111/j.1747-4949.2007.00142.x. - DOI - PubMed

[4] Wang YL, Wu D, Liao X, Zhang W, Zhao X, Wang YJ. Burden of stroke in China. Int J Stroke. 2007;2:211–213. doi: 10.1111/j.1747-4949.2007.00142.x. - DOI - PubMed

[5] Wang Y, Zhao X, Jiang Y, Li H, Wang L, Johnston SC, et al. Prevalence, knowledge, and treatment of transient ischemic attacks in China. Neurology. 2015;84:2354–2361. doi: 10.1212/WNL.0000000000001665. - DOI - PMC - PubMed

[6] Wang Y, Zhao X, Jiang Y, Li H, Wang L, Johnston SC, et al. Prevalence, knowledge, and treatment of transient ischemic attacks in China. Neurology. 2015;84:2354–2361. doi: 10.1212/WNL.0000000000001665. - DOI - PMC - PubMed

[7] Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370:1432–1442. doi: 10.1016/S0140-6736(07)61448-2. - DOI - PubMed

[8] Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370:1432–1442. doi: 10.1016/S0140-6736(07)61448-2. - DOI - PubMed

[9] Castle J, Mlynash M, Lee K, Caulfield AF, Wolford C, Kemp S, et al. Agreement regarding diagnosis of transient ischemic attack fairly low among stroke-trained neurologists. Stroke. 2010;41:1367–1370. doi: 10.1161/STROKEAHA.109.577650. - DOI - PubMed

[10] Castle J, Mlynash M, Lee K, Caulfield AF, Wolford C, Kemp S, et al. Agreement regarding diagnosis of transient ischemic attack fairly low among stroke-trained neurologists. Stroke. 2010;41:1367–1370. doi: 10.1161/STROKEAHA.109.577650. - DOI - PubMed

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Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

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Blood Biomarkers in Minor Stroke and Transient Ischemic Attack

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