Review
doi: 10.1002/anie.201602164.
Epub 2016 Jul 20.
A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)
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- PMID: 27435664
- DOI: 10.1002/anie.201602164
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Review
A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)
Angew Chem Int Ed Engl.
.
Abstract
Japanese soil was the origin of one of the most important drugs of the world: ivermectin. No other drug has such importance for the health of millions of people, particularly in the poor regions of the world. The discovery of the parent compounds of the avermectines is described first hand by S. Ōmura.
Keywords: anthelmintics; ivermectin; medicinal chemistry; river blindness; worm infestation.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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