Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

doi:10.1007/s00268-016-3798-1

. 2017 Feb;41(2):562-573.

doi: 10.1007/s00268-016-3798-1.

Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

Woohyung Lee^{1

2}, Yoo-Seok Yoon³, Ho-Seong Han¹, Jin Young Jang⁴, Jai Young Cho¹, Woohyun Jung⁴, Wooil Kwon⁴, YoungRok Choi¹, Sun-Whe Kim⁴

Affiliations

¹ Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-Si, Gyeonggi-do, 463-707, Republic of Korea.
² Department of Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
³ Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-Si, Gyeonggi-do, 463-707, Republic of Korea. yoonys@snubh.org.
⁴ Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

PMID: 27834017
DOI: 10.1007/s00268-016-3798-1

Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

Woohyung Lee et al. World J Surg. 2017 Feb.

. 2017 Feb;41(2):562-573.

doi: 10.1007/s00268-016-3798-1.

Authors

Woohyung Lee^{1

2}, Yoo-Seok Yoon³, Ho-Seong Han¹, Jin Young Jang⁴, Jai Young Cho¹, Woohyun Jung⁴, Wooil Kwon⁴, YoungRok Choi¹, Sun-Whe Kim⁴

Affiliations

¹ Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-Si, Gyeonggi-do, 463-707, Republic of Korea.
² Department of Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
³ Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-Si, Gyeonggi-do, 463-707, Republic of Korea. yoonys@snubh.org.
⁴ Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

PMID: 27834017
DOI: 10.1007/s00268-016-3798-1

Erratum in

Erratum to: Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma.
Lee W, Yoon YS, Han HS, Jang JY, Cho JY, Jung W, Kwon W, Choi Y, Kim SW. Lee W, et al. World J Surg. 2017 Feb;41(2):559-561. doi: 10.1007/s00268-016-3836-z. World J Surg. 2017. PMID: 27878348 No abstract available.

Abstract

Background: Although the role of adjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC) is well established, its optimal timing and duration are still controversial.

Methods: The study included 311 patients with PDAC who underwent curative resection followed by adjuvant therapy. We analyzed survival data according to the timing of initiation and completion of adjuvant therapy.

Results: There were no differences in 5-year overall survival (OS) (32.8 vs. 35.4%, p = 0.539) and disease-free survival (DFS) rates (26.2 vs. 23.3%, p = 0.865) between early (≤6 weeks) and late (>6 weeks) initiation of adjuvant therapy. However, the 5-year OS (42.6 vs. 22.2%, p < 0.001) and DFS (29.2 vs. 18.4%, p = 0.042) rates were significantly greater in patients with complete versus incomplete adjuvant therapy. Multivariable analysis revealed that incomplete adjuvant therapy was an independent prognostic factor for decreased OS (p = 0.001; hazard ratio 1.850; 95% confidence interval 1.266-2.702).

Conclusions: The results show that complete adjuvant therapy is a more important prognostic factor than early initiation for improving the survival of patients with resected PDAC.

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[1] Pract Radiat Oncol. 2014 Mar-Apr;4(2):e117-23 - PubMed

[2] Pract Radiat Oncol. 2014 Mar-Apr;4(2):e117-23 - PubMed

[3] J Clin Oncol. 2014 Feb 20;32(6):504-12 - PubMed

[4] J Clin Oncol. 2014 Feb 20;32(6):504-12 - PubMed

[5] Gastroenterology. 2005 May;128(6):1626-41 - PubMed

[6] Gastroenterology. 2005 May;128(6):1626-41 - PubMed

[7] N Engl J Med. 1992 Feb 13;326(7):455-65 - PubMed

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[9] Am J Surg. 2016 Apr;211(4):787-92 - PubMed

[10] Am J Surg. 2016 Apr;211(4):787-92 - PubMed

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Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

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Prognostic Relevance of the Timing of Initiating and the Completion of Adjuvant Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma

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