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. 2017 Feb;25(2):401-407.
doi: 10.1002/oby.21728. Epub 2016 Dec 27.

Initial body fat gain is related to brain volume changes in adolescents: A repeated-measures voxel-based morphometry study

Sonja Yokum  1 , Eric Stice  1
Affiliations

Initial body fat gain is related to brain volume changes in adolescents: A repeated-measures voxel-based morphometry study

Sonja Yokum et al. Obesity (Silver Spring). 2017 Feb.

Abstract

Objective: Individuals with obesity versus those within a healthy weight range show brain volume differences, but it is unclear whether these differences reflect initial vulnerability factors or are secondary to weight gain.

Methods: One hundred sixty-two adolescents (M age = 15.3 ± 1.1; 81 females) with healthy weight were scanned at baseline. Sixty subjects (M baseline age: 15.2 ± 1.1; M follow-up age: 17.7 ± 1.2; 34 females) completed a second scan at 2- or 3-year follow-up. Voxel-based morphometry assessed global and regional gray matter (GM) and white matter (WM) volumes. Body fat percentage was assessed yearly over follow-up.

Results: Baseline global/regional GM/WM volume did not predict body fat gain over follow-up. Adolescents who gained body fat showed greater decreases in GM volume in the putamen compared with those who showed loss of body fat. Adolescents who gained body fat showed greater increases in WM volume in the anterior cingulate cortex compared with those who showed stability of or loss of body fat.

Conclusions: Body fat gain versus stability and loss produce GM and WM volume changes, rather than baseline volumetric differences predicting body fat gain.

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Figures

Figure 1
Figure 1
Participant flow chart.
Figure 2
Figure 2
A) Decreases in regional GM volume in right putamen (MNI coordinates: = 36, −16, −9, Z = 4.04, pFWE = 0.003, k = 930) and B) increases in regional WM volume in right ACC (MNI coordinates: 11, 33, 7, Z = 4.01, pFWE = 0.001, k = 817) in the body fat gain versus body fat loss group (n = 14) over follow-up.
See this image and copyright information in PMC

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References

    1. Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, et al. Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988-1994 Through 2013-2014. JAMA. 2016;315(21):2292–2299. - PMC - PubMed
    1. The NS, Suchindran C, North KE, Popkin BM, Gordon-Larsen P. Association of adolescent obesity with risk of severe obesity in adulthood. JAMA. 2010;304(18):2042–2047. - PMC - PubMed
    1. Turk MW, Yang K, Hravnak M, Sereika SM, Ewing LJ, Burke LE. Randomized clinical trials of weight loss maintenance: a review. J Cardiovasc Nurs. 2009;24(1):58–80. - PMC - PubMed
    1. Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM. Altered hypothalamic response to food in smokers. AJCN. 2013;97(1):15–22. - PMC - PubMed
    1. Stice E, Burger KS, Yokum S. Reward Region Responsivity Predicts Future Weight Gain and Moderating Effects of the TaqIA Allele. J Neurosci. 2015;35(28):10316–10324. - PMC - PubMed

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