The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis

doi:10.1016/j.breast.2017.04.003

Review

. 2017 Jun:33:166-177.

doi: 10.1016/j.breast.2017.04.003. Epub 2017 Apr 14.

The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis

L K Juvet¹, I Thune², I K Ø Elvsaas³, E A Fors⁴, S Lundgren⁵, G Bertheussen⁶, G Leivseth⁷, L M Oldervoll⁸

Affiliations

¹ Norwegian Institute of Public Health, Oslo, Norway; University College of Southeast Norway, Kongsberg, Norway. Electronic address: LeneKristine.Juvet@fhi.no.
² The Cancer Centre, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, The Artic University of Tromsø, Norway.
³ Norwegian Institute of Public Health, Oslo, Norway.
⁴ Department of Public Health and Nursing, and General Practice Research Unit, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
⁵ Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway; Department of Oncology, St. Olavs University Hospital, Trondheim, Norway.
⁶ Dept. of Neuromedicine and Movementscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St Olav University Hospital, Trondheim, Norway.
⁷ Department of Neuroscience, NTNU, Trondheim, Norway; Hokksund Medical Rehabilitation Centre, Hokksund, Norway; Department of Clinical Medicine, Neuromuscular Disorders Research Group, The Arctic University of Norway, Tromsø, Norway.
⁸ Department of Social Work and Health Science, NTNU, Norway; Norwegian Heart and Lung Association (LHL)/ LHL-Clinics, Oslo, Norway.

PMID: 28415013
DOI: 10.1016/j.breast.2017.04.003

Review

The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis

L K Juvet et al. Breast. 2017 Jun.

. 2017 Jun:33:166-177.

doi: 10.1016/j.breast.2017.04.003. Epub 2017 Apr 14.

Authors

L K Juvet¹, I Thune², I K Ø Elvsaas³, E A Fors⁴, S Lundgren⁵, G Bertheussen⁶, G Leivseth⁷, L M Oldervoll⁸

Affiliations

¹ Norwegian Institute of Public Health, Oslo, Norway; University College of Southeast Norway, Kongsberg, Norway. Electronic address: LeneKristine.Juvet@fhi.no.
² The Cancer Centre, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, The Artic University of Tromsø, Norway.
³ Norwegian Institute of Public Health, Oslo, Norway.
⁴ Department of Public Health and Nursing, and General Practice Research Unit, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
⁵ Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway; Department of Oncology, St. Olavs University Hospital, Trondheim, Norway.
⁶ Dept. of Neuromedicine and Movementscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St Olav University Hospital, Trondheim, Norway.
⁷ Department of Neuroscience, NTNU, Trondheim, Norway; Hokksund Medical Rehabilitation Centre, Hokksund, Norway; Department of Clinical Medicine, Neuromuscular Disorders Research Group, The Arctic University of Norway, Tromsø, Norway.
⁸ Department of Social Work and Health Science, NTNU, Norway; Norwegian Heart and Lung Association (LHL)/ LHL-Clinics, Oslo, Norway.

PMID: 28415013
DOI: 10.1016/j.breast.2017.04.003

Abstract

Breast cancer is the leading cause of cancer in women worldwide. Exercise interventions may improve physical and psychological factors during and after active breast cancer treatment. The aim of this systematic review was to assess the current knowledge regarding the efficacy of physical exercise with respect to fatigue and self-reported physical functioning. Systematic searches in Cochrane Library, Medline, Embase, Cinahl, PsycINFO, AMED and PEDro. After assessing the quality of the studies, we identified 25 randomized controlled trials that included 3418 breast cancer patients. An increase in physical functioning and a decrease in fatigue were observed after a physical exercise intervention, with an SMD of 0.27 (0.12, 0.41) and -0.32 (-0.49, - 0.14), respectively. There were slightly higher improvements in physical functioning and fatigue when the patients received the intervention after adjuvant breast cancer treatment. The 6-month follow-up data showed a small favourable difference for the physical exercise group for both physical functioning and fatigue. This systematic review found that an exercise intervention program can produce short-term improvements in physical functioning and can reduce fatigue in breast cancer patients. However, more studies are needed to confirm the time-dependent observations in this study.

Keywords: Breast cancer; Exercise; Fatigue; Physical functioning; Quality of life.

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The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis

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The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis

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